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- W2000773787 abstract "Two potent dopamine transporter ligands, 2β-[O-11CH3]-carbomethoxy-3β-(4-methylphenyl)tropane and its 4-chlorophenyl analogue, were synthesized by O-alkylation at the 2β-carboxy position with [11C]-iodomethane. Separation of the [11C]-labelled tropane from excess carboxylic acid precursor was readily achieved by semipreparative HPLC providing pure radiotracers at high specific activities (800–3000 mCi/μmole) suitable for in vivo PET studies. Radiosynthesis of this class of compounds by [O-11CH3]-methylation offers advantages over previously reported [N-11CH3]-methylation methods." @default.
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- W2000773787 date "1994-08-01" @default.
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- W2000773787 title "Facile radiolabelling and purification of 2β-[O-11CH3]-carbomethoxy-3β-aryltropanes: Radiotracers for the dopamine transporter" @default.
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- W2000773787 doi "https://doi.org/10.1002/jlcr.2580340809" @default.
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