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- W2000774443 abstract "To evaluate both the incidence of c-myc gene mutation and the relationship of this finding to the clinico-pathologic characteristics of patients with cervical cancer, a polymerase chain reaction (PCR)-based heteroduplex gel electrophoresis method was used to screen DNA extracted from 102 cervical invasive carcinomas referred to the Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, C-myc mutation was detected and then characterised by sequencing of PCR products in 4 cases (4%). The incidence of c-myc mutation in patients with advanced stage tumours (stage III–IV, 11 %) was statistically higher than in those with early stages (stage I–II, 1 %, p = 0.05). There was also a significant difference in the incidence of c-myc mutation among the patients who had died of their disease (10%), were alive with evidence of disease (25%), and those without evidence of disease (0%, p = 0.0003). These findings indicate that the c-myc mutation is not common in cervical cancer, but where it exists, it may be associated with cancer progression and poorer outcome. Whether the c-myc mutation is an adjunct prognostic indicator in cervical cancer remains to be established in a larger study." @default.
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- W2000774443 date "1997-01-01" @default.
- W2000774443 modified "2023-10-12" @default.
- W2000774443 title "C-<i>myc</i>Mutation Detected by Polymerase Chain Reaction – Heteroduplex in Cervical Cancer" @default.
- W2000774443 doi "https://doi.org/10.1159/000291505" @default.
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