FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000775199> ?p ?o ?g. }

• W2000775199 endingPage "5" @default.
• W2000775199 startingPage "1" @default.
• W2000775199 abstract "The purpose of this study was to determine the effects of PCBs and PBBs on peroxisome proliferator-activated receptor-<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=E1><mml:mo>α</mml:mo></mml:math>-(PPAR<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=E2><mml:mo>α</mml:mo></mml:math>-) associated enzyme activities or protein levels. Male Sprague-Dawley rats were administered a single IP injection (150 <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=E3><mml:mo>μ</mml:mo></mml:math>mol/kg) of either 3,3′,4,4′-tetrabromobiphenyl, 3,3′,4,4′-tetrachlorobiphenyl, 3,3′,5,5′-tetrabromobiphenyl, 2′,3,3′,4,5-pentachlorobiphenyl, 3,3′,4,4′,5-pentachlorobiphenyl, 2,2′,3,3′,5,5′-hexachlorobiphenyl, or 3,3′,4,4′,5,5′-hexabromobiphenyl in corn oil (10 ml/kg). One week later, the activities of catalase, peroxisomal fatty acyl-CoA oxidase, and peroxisomal beta-oxidation as well as cytochrome P450 4A (CYP4A) protein content were determined in subcellular liver fractions. None of the peroxisomal enzyme activities were significantly increased by any of the halogenated biphenyl congeners tested. Except for minor (approx. 25%) increases in the total CYP4A content following treatment with 2,2′,3,3′,5,5′-hexachlorobiphenyl and 3,3′,5,5′-tetrabromobiphenyl, CYP4A protein contents were not increased by any treatment. The two Ah receptor agonists, 3,3′,4,4′-tetrabromobiphenyl and 3,3′,4,4′,5-pentachlorobiphenyl, significantly diminished the liver content of CYP4A proteins and activities of the peroxisomal enzymes studied. Since a range of congeners with different biologic and toxicologic activities were selected for this study, it may be concluded that the polyhalogenated biphenyls do not induce peroxisome proliferation in the male rat, but rather certain members of this class of compounds down regulate peroxisome-associated enzymes. Since PCBs and PBBs do not increase enzyme activities and expression of proteins associated with PPAR<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=E4><mml:mo>α</mml:mo></mml:math>, these agents are therefore exerting their carcinogenic and promoting activities by some other mechanism." @default.
• W2000775199 created "2016-06-24" @default.
• W2000775199 creator A5017943532 @default.
• W2000775199 creator A5032896829 @default.
• W2000775199 creator A5047676862 @default.
• W2000775199 creator A5059620735 @default.
• W2000775199 creator A5065258484 @default.
• W2000775199 creator A5068357698 @default.
• W2000775199 creator A5081672477 @default.
• W2000775199 creator A5088213444 @default.
• W2000775199 date "2007-01-01" @default.
• W2000775199 modified "2023-10-15" @default.
• W2000775199 title "Suppression of Peroxisomal Enzyme Activities and Cytochrome P450 4A Isozyme Expression by Congeneric Polybrominated and Polychlorinated Biphenyls" @default.
• W2000775199 cites W1523227020 @default.
• W2000775199 cites W1587160304 @default.
• W2000775199 cites W1768247331 @default.
• W2000775199 cites W1775749144 @default.
• W2000775199 cites W1969081737 @default.
• W2000775199 cites W1971839334 @default.
• W2000775199 cites W1974981229 @default.
• W2000775199 cites W1975172478 @default.
• W2000775199 cites W1984919610 @default.
• W2000775199 cites W1987598153 @default.
• W2000775199 cites W2002965023 @default.
• W2000775199 cites W2013875520 @default.
• W2000775199 cites W2026131954 @default.
• W2000775199 cites W2030678009 @default.
• W2000775199 cites W2038584428 @default.
• W2000775199 cites W2039446053 @default.
• W2000775199 cites W2048648964 @default.
• W2000775199 cites W2063043675 @default.
• W2000775199 cites W2063442910 @default.
• W2000775199 cites W2080991518 @default.
• W2000775199 cites W2084727662 @default.
• W2000775199 cites W2100837269 @default.
• W2000775199 cites W2101108802 @default.
• W2000775199 cites W2126644867 @default.
• W2000775199 cites W2156624314 @default.
• W2000775199 cites W2168300082 @default.
• W2000775199 cites W2219509325 @default.
• W2000775199 cites W2397594219 @default.
• W2000775199 cites W2399940392 @default.
• W2000775199 cites W2403675971 @default.
• W2000775199 cites W4231523688 @default.
• W2000775199 cites W4233669691 @default.
• W2000775199 cites W62982708 @default.
• W2000775199 doi "https://doi.org/10.1155/2007/15481" @default.
• W2000775199 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2220027" @default.
• W2000775199 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18274624" @default.
• W2000775199 hasPublicationYear "2007" @default.
• W2000775199 type Work @default.
• W2000775199 sameAs 2000775199 @default.
• W2000775199 citedByCount "9" @default.
• W2000775199 countsByYear W20007751992014 @default.
• W2000775199 countsByYear W20007751992015 @default.
• W2000775199 countsByYear W20007751992016 @default.
• W2000775199 countsByYear W20007751992017 @default.
• W2000775199 countsByYear W20007751992018 @default.
• W2000775199 countsByYear W20007751992022 @default.
• W2000775199 crossrefType "journal-article" @default.
• W2000775199 hasAuthorship W2000775199A5017943532 @default.
• W2000775199 hasAuthorship W2000775199A5032896829 @default.
• W2000775199 hasAuthorship W2000775199A5047676862 @default.
• W2000775199 hasAuthorship W2000775199A5059620735 @default.
• W2000775199 hasAuthorship W2000775199A5065258484 @default.
• W2000775199 hasAuthorship W2000775199A5068357698 @default.
• W2000775199 hasAuthorship W2000775199A5081672477 @default.
• W2000775199 hasAuthorship W2000775199A5088213444 @default.
• W2000775199 hasBestOaLocation W20007751991 @default.
• W2000775199 hasConcept C119795356 @default.
• W2000775199 hasConcept C127078168 @default.
• W2000775199 hasConcept C170493617 @default.
• W2000775199 hasConcept C181199279 @default.
• W2000775199 hasConcept C185592680 @default.
• W2000775199 hasConcept C526171541 @default.
• W2000775199 hasConcept C55493867 @default.
• W2000775199 hasConceptScore W2000775199C119795356 @default.
• W2000775199 hasConceptScore W2000775199C127078168 @default.
• W2000775199 hasConceptScore W2000775199C170493617 @default.
• W2000775199 hasConceptScore W2000775199C181199279 @default.
• W2000775199 hasConceptScore W2000775199C185592680 @default.
• W2000775199 hasConceptScore W2000775199C526171541 @default.
• W2000775199 hasConceptScore W2000775199C55493867 @default.
• W2000775199 hasFunder F4320332161 @default.
• W2000775199 hasLocation W20007751991 @default.
• W2000775199 hasLocation W20007751992 @default.
• W2000775199 hasLocation W20007751993 @default.
• W2000775199 hasLocation W20007751994 @default.
• W2000775199 hasLocation W20007751995 @default.
• W2000775199 hasLocation W20007751996 @default.
• W2000775199 hasOpenAccess W2000775199 @default.
• W2000775199 hasPrimaryLocation W20007751991 @default.
• W2000775199 hasRelatedWork W1550996414 @default.
• W2000775199 hasRelatedWork W1978392142 @default.
• W2000775199 hasRelatedWork W2037443437 @default.
• W2000775199 hasRelatedWork W2050182051 @default.
• W2000775199 hasRelatedWork W2060038873 @default.
• W2000775199 hasRelatedWork W2162897583 @default.

• next