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- W2000776191 abstract "The administration of glucocorticoid hormone to rapidly growing weanling rats results in a virtually complete inhibition of liver DNA synthesis. It is shown that upon cessation of treatment not only is there a prompt resumption of liver DNA synthesis, but that synthesis actually proceeds at a rate greatly exceeding that in control animals. The burst of new DNA synthesis which follows the release of the cortisone-induced inhibition represents an approximate doubling of the normal rate of synthesis and continues until the DNA content of the livers of the steroid-treated animals reaches that of the untreated controls. The demonstration that cessation of steroid treatment is followed not only by a period of rapid body weight gain but by a genuine acceleration of hyperplasia as well substantiates the earlier but hitherto unproven concept of post-steroid “catch-up” growth. A detailed comparison of the sequence of changes in liver DNA synthesis with that of changes in liver DNA polymerase activity makes it unlikely that the level of polymerase activity, at least as measured under standard in vitro conditions, plays a primary role in the regulation of the rate of liver DNA synthesis in vivo. It is furthermore shown that neither the fall in polymerase activity nor the inhibition of DNA synthesis in the livers of cortisone-treated animals can be accounted for by a glucocorticoid-induced suppression of growth hormone secretion. (Endocrinology94: 1637, 1974)" @default.
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- W2000776191 date "1974-06-01" @default.
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- W2000776191 title "Hormone-Induced Changes in Liver DNA Synthesis:Effects of Glucocorticoids and Growth Hormone on Liver Growth and DNA Polymerase Activity" @default.
- W2000776191 doi "https://doi.org/10.1210/endo-94-6-1637" @default.
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