Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000778831> ?p ?o ?g. }
- W2000778831 endingPage "45" @default.
- W2000778831 startingPage "33" @default.
- W2000778831 abstract "Sixteen colonic tumours and 10 normal mucosa biopsies have been examined by 1H NMR spectroscopy at 9.4 T. A complete characterization and quantification of the aliphatic region of PCA extract spectra and the analysis of the two-dimensional COSY spectra of five pairs of intact biopsies (tumor and control mucosa) has been carried out. The analysis of the PCA extracts demonstrated a significant increase in the concentration of the endogenous compounds: lactate, glutamate, aspartate, taurine, spermine, glutathione and glycerophosphoethanolamine, and a significant decrease of myo- and scyllo-inositol, in tumours with respect to mucosae. Among these metabolites, the high myo-inositol and taurine levels and the reciprocal changes found between them in tumours and mucosae make their resonances interesting as possible malignancy markers if they are detectable in vivo. In contrast to the easy observation of taurine in one-dimensional spectra of intact biopsies, the difficulty of observing myo-inositol prompted us to use two-dimensional COSY spectra for the detection and quantification of both these metabolites. In the two-dimensional spectra, the use of a ratio between the cross-peak volumes of both metabolites permits an excellent differentiation between tumours and normal mucosa and suggests its potential to detect malignant changes in the healthy tissue, provided a two-dimensional approach is used." @default.
- W2000778831 created "2016-06-24" @default.
- W2000778831 creator A5000869840 @default.
- W2000778831 creator A5068194631 @default.
- W2000778831 date "1996-02-01" @default.
- W2000778831 modified "2023-10-16" @default.
- W2000778831 title "Quantitative and Qualitative Characterization of1H NMR Spectra of Colon Tumors, Normal Mucosa and their Perchloric Acid Extracts: Decreased Levels of Myo-inositol in Tumours can be Detected in Intact Biopsies" @default.
- W2000778831 cites W1224356026 @default.
- W2000778831 cites W141193853 @default.
- W2000778831 cites W1493943284 @default.
- W2000778831 cites W1612466044 @default.
- W2000778831 cites W1645633844 @default.
- W2000778831 cites W1783564941 @default.
- W2000778831 cites W1966609073 @default.
- W2000778831 cites W1969810164 @default.
- W2000778831 cites W1971832431 @default.
- W2000778831 cites W1980861344 @default.
- W2000778831 cites W1988916423 @default.
- W2000778831 cites W1994856847 @default.
- W2000778831 cites W2001042577 @default.
- W2000778831 cites W2002408619 @default.
- W2000778831 cites W2010528272 @default.
- W2000778831 cites W2012834817 @default.
- W2000778831 cites W2016985284 @default.
- W2000778831 cites W2020413182 @default.
- W2000778831 cites W2023783596 @default.
- W2000778831 cites W2024050733 @default.
- W2000778831 cites W2024873594 @default.
- W2000778831 cites W2025349762 @default.
- W2000778831 cites W2035057990 @default.
- W2000778831 cites W2039602171 @default.
- W2000778831 cites W2046171723 @default.
- W2000778831 cites W2055845567 @default.
- W2000778831 cites W2058107898 @default.
- W2000778831 cites W2058239646 @default.
- W2000778831 cites W2062839018 @default.
- W2000778831 cites W2064296885 @default.
- W2000778831 cites W2064618223 @default.
- W2000778831 cites W2067023319 @default.
- W2000778831 cites W2068836668 @default.
- W2000778831 cites W2070881094 @default.
- W2000778831 cites W2073346029 @default.
- W2000778831 cites W2076481604 @default.
- W2000778831 cites W2076557506 @default.
- W2000778831 cites W2079997496 @default.
- W2000778831 cites W2088924434 @default.
- W2000778831 cites W2096164323 @default.
- W2000778831 cites W2101622496 @default.
- W2000778831 cites W2111288568 @default.
- W2000778831 cites W2158877135 @default.
- W2000778831 cites W2474169300 @default.
- W2000778831 cites W2501728120 @default.
- W2000778831 cites W4250876040 @default.
- W2000778831 cites W989436662 @default.
- W2000778831 cites W994503810 @default.
- W2000778831 doi "https://doi.org/10.1002/(sici)1099-1492(199602)9:1<33::aid-nbm391>3.0.co;2-g" @default.
- W2000778831 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8842031" @default.
- W2000778831 hasPublicationYear "1996" @default.
- W2000778831 type Work @default.
- W2000778831 sameAs 2000778831 @default.
- W2000778831 citedByCount "68" @default.
- W2000778831 countsByYear W20007788312012 @default.
- W2000778831 countsByYear W20007788312013 @default.
- W2000778831 countsByYear W20007788312014 @default.
- W2000778831 countsByYear W20007788312015 @default.
- W2000778831 countsByYear W20007788312016 @default.
- W2000778831 countsByYear W20007788312017 @default.
- W2000778831 countsByYear W20007788312018 @default.
- W2000778831 countsByYear W20007788312019 @default.
- W2000778831 countsByYear W20007788312020 @default.
- W2000778831 countsByYear W20007788312021 @default.
- W2000778831 countsByYear W20007788312022 @default.
- W2000778831 crossrefType "journal-article" @default.
- W2000778831 hasAuthorship W2000778831A5000869840 @default.
- W2000778831 hasAuthorship W2000778831A5068194631 @default.
- W2000778831 hasConcept C126322002 @default.
- W2000778831 hasConcept C142724271 @default.
- W2000778831 hasConcept C150903083 @default.
- W2000778831 hasConcept C170493617 @default.
- W2000778831 hasConcept C181199279 @default.
- W2000778831 hasConcept C185592680 @default.
- W2000778831 hasConcept C207001950 @default.
- W2000778831 hasConcept C2775934546 @default.
- W2000778831 hasConcept C2776109719 @default.
- W2000778831 hasConcept C2777427919 @default.
- W2000778831 hasConcept C2777477808 @default.
- W2000778831 hasConcept C2779701627 @default.
- W2000778831 hasConcept C3019368612 @default.
- W2000778831 hasConcept C515207424 @default.
- W2000778831 hasConcept C538909803 @default.
- W2000778831 hasConcept C55493867 @default.
- W2000778831 hasConcept C71924100 @default.
- W2000778831 hasConcept C86803240 @default.
- W2000778831 hasConceptScore W2000778831C126322002 @default.
- W2000778831 hasConceptScore W2000778831C142724271 @default.
- W2000778831 hasConceptScore W2000778831C150903083 @default.
- W2000778831 hasConceptScore W2000778831C170493617 @default.
- W2000778831 hasConceptScore W2000778831C181199279 @default.