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- W2000778861 abstract "A 7-year-old boy presented with pyoderma gangrenosum. Extensive studies failed to show an etiological agent. Therapy with antibiotics, antifungal agents, topical medications, and corticosteroids did not result in healing of his skin lesions. He had hypergammaglobulinemia with increase in all of the three main immunoglobulins, and plasmacytosis of the bone marrow. Treatment with 6-mercaptopurine resulted in complete healing of the skin lesions. One year after cessation of therapy he developed acute leukemia. The association of immunoglobulin disorders with pyoderma gangrenosum and the relationship between autoimmune diseases, immunosuppressive therapy, and the development of leukemias and lymphomas are discussed. A 7-year-old boy presented with pyoderma gangrenosum. Extensive studies failed to show an etiological agent. Therapy with antibiotics, antifungal agents, topical medications, and corticosteroids did not result in healing of his skin lesions. He had hypergammaglobulinemia with increase in all of the three main immunoglobulins, and plasmacytosis of the bone marrow. Treatment with 6-mercaptopurine resulted in complete healing of the skin lesions. One year after cessation of therapy he developed acute leukemia. The association of immunoglobulin disorders with pyoderma gangrenosum and the relationship between autoimmune diseases, immunosuppressive therapy, and the development of leukemias and lymphomas are discussed." @default.
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- W2000778861 date "1968-03-01" @default.
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- W2000778861 title "Pyoderma gangrenosum treated with6-mercaptopurine and followed by acute leukemia" @default.
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- W2000778861 doi "https://doi.org/10.1016/s0022-3476(68)80218-5" @default.
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