Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000779844> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2000779844 endingPage "347" @default.
- W2000779844 startingPage "340" @default.
- W2000779844 abstract "Metformin is a first-line drug for the treatment of type 2 diabetes (T2D) and is often prescribed in combination with other drugs to control a patient's blood glucose level and achieve their HbA1c goal. New treatment options for T2D will likely include fixed dose combinations with metformin, which may require preclinical combination toxicology studies. To date, there are few published reports evaluating the toxicity of metformin alone to aid in the design of these studies. Therefore, to understand the toxicity of metformin alone, Crl:CD(SD) rats were administered metformin at 0, 200, 600, 900 or 1200 mg/kg/day by oral gavage for 13 weeks. Administration of > or =900 mg/kg/day resulted in moribundity/mortality and clinical signs of toxicity. Other adverse findings included increased incidence of minimal necrosis with minimal to slight inflammation of the parotid salivary gland for males given 1200 mg/kg/day, body weight loss and clinical signs in rats given > or =600 mg/kg/day. Metformin was also associated with evidence of minimal metabolic acidosis (increased serum lactate and beta-hydroxybutyric acid and decreased serum bicarbonate and urine pH) at doses > or =600 mg/kg/day. There were no significant sex differences in mean AUC(0-24) or C(max) nor were there significant differences in mean AUC(0-24) or C(max) following repeated dosing compared to a single dose. The no observable adverse effect level (NOAEL) was 200 mg/kg/day (mean AUC(0-24)=41.1 microg h/mL; mean C(max)=10.3 microg/mL based on gender average week 13 values). These effects should be taken into consideration when assessing potential toxicities of metformin in fixed dose combinations." @default.
- W2000779844 created "2016-06-24" @default.
- W2000779844 creator A5003737691 @default.
- W2000779844 creator A5015238083 @default.
- W2000779844 creator A5035004333 @default.
- W2000779844 creator A5043037306 @default.
- W2000779844 creator A5044614619 @default.
- W2000779844 creator A5045272190 @default.
- W2000779844 creator A5071913007 @default.
- W2000779844 creator A5072661923 @default.
- W2000779844 date "2010-03-15" @default.
- W2000779844 modified "2023-10-16" @default.
- W2000779844 title "Toxicity and toxicokinetics of metformin in rats" @default.
- W2000779844 cites W1584324651 @default.
- W2000779844 cites W2018247947 @default.
- W2000779844 cites W2020638064 @default.
- W2000779844 cites W2020831729 @default.
- W2000779844 cites W2051194953 @default.
- W2000779844 cites W2056347227 @default.
- W2000779844 cites W2071723829 @default.
- W2000779844 cites W2072329525 @default.
- W2000779844 cites W2081532336 @default.
- W2000779844 cites W2100076167 @default.
- W2000779844 cites W2102382908 @default.
- W2000779844 cites W2142504521 @default.
- W2000779844 cites W2417742395 @default.
- W2000779844 cites W2113901579 @default.
- W2000779844 doi "https://doi.org/10.1016/j.taap.2009.11.026" @default.
- W2000779844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20004680" @default.
- W2000779844 hasPublicationYear "2010" @default.
- W2000779844 type Work @default.
- W2000779844 sameAs 2000779844 @default.
- W2000779844 citedByCount "75" @default.
- W2000779844 countsByYear W20007798442012 @default.
- W2000779844 countsByYear W20007798442013 @default.
- W2000779844 countsByYear W20007798442014 @default.
- W2000779844 countsByYear W20007798442015 @default.
- W2000779844 countsByYear W20007798442016 @default.
- W2000779844 countsByYear W20007798442017 @default.
- W2000779844 countsByYear W20007798442018 @default.
- W2000779844 countsByYear W20007798442019 @default.
- W2000779844 countsByYear W20007798442020 @default.
- W2000779844 countsByYear W20007798442021 @default.
- W2000779844 countsByYear W20007798442022 @default.
- W2000779844 countsByYear W20007798442023 @default.
- W2000779844 crossrefType "journal-article" @default.
- W2000779844 hasAuthorship W2000779844A5003737691 @default.
- W2000779844 hasAuthorship W2000779844A5015238083 @default.
- W2000779844 hasAuthorship W2000779844A5035004333 @default.
- W2000779844 hasAuthorship W2000779844A5043037306 @default.
- W2000779844 hasAuthorship W2000779844A5044614619 @default.
- W2000779844 hasAuthorship W2000779844A5045272190 @default.
- W2000779844 hasAuthorship W2000779844A5071913007 @default.
- W2000779844 hasAuthorship W2000779844A5072661923 @default.
- W2000779844 hasConcept C112705442 @default.
- W2000779844 hasConcept C126322002 @default.
- W2000779844 hasConcept C134018914 @default.
- W2000779844 hasConcept C195289149 @default.
- W2000779844 hasConcept C197934379 @default.
- W2000779844 hasConcept C2777180221 @default.
- W2000779844 hasConcept C2777288759 @default.
- W2000779844 hasConcept C2780323712 @default.
- W2000779844 hasConcept C29730261 @default.
- W2000779844 hasConcept C555293320 @default.
- W2000779844 hasConcept C71924100 @default.
- W2000779844 hasConcept C98274493 @default.
- W2000779844 hasConceptScore W2000779844C112705442 @default.
- W2000779844 hasConceptScore W2000779844C126322002 @default.
- W2000779844 hasConceptScore W2000779844C134018914 @default.
- W2000779844 hasConceptScore W2000779844C195289149 @default.
- W2000779844 hasConceptScore W2000779844C197934379 @default.
- W2000779844 hasConceptScore W2000779844C2777180221 @default.
- W2000779844 hasConceptScore W2000779844C2777288759 @default.
- W2000779844 hasConceptScore W2000779844C2780323712 @default.
- W2000779844 hasConceptScore W2000779844C29730261 @default.
- W2000779844 hasConceptScore W2000779844C555293320 @default.
- W2000779844 hasConceptScore W2000779844C71924100 @default.
- W2000779844 hasConceptScore W2000779844C98274493 @default.
- W2000779844 hasIssue "3" @default.
- W2000779844 hasLocation W20007798441 @default.
- W2000779844 hasLocation W20007798442 @default.
- W2000779844 hasOpenAccess W2000779844 @default.
- W2000779844 hasPrimaryLocation W20007798441 @default.
- W2000779844 hasRelatedWork W2004325424 @default.
- W2000779844 hasRelatedWork W2005084305 @default.
- W2000779844 hasRelatedWork W2016264464 @default.
- W2000779844 hasRelatedWork W2033313326 @default.
- W2000779844 hasRelatedWork W2111269218 @default.
- W2000779844 hasRelatedWork W2122811361 @default.
- W2000779844 hasRelatedWork W2744240433 @default.
- W2000779844 hasRelatedWork W2774225352 @default.
- W2000779844 hasRelatedWork W2793520024 @default.
- W2000779844 hasRelatedWork W3002798077 @default.
- W2000779844 hasVolume "243" @default.
- W2000779844 isParatext "false" @default.
- W2000779844 isRetracted "false" @default.
- W2000779844 magId "2000779844" @default.
- W2000779844 workType "article" @default.