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- W2000780057 abstract "Abstract To investigate the relationship between plasma levels of leukotriene E 4 (LTE 4 ) and the forced expiratory volume in 1 second (FEV 1 ), we measured the concentration of LTE 4 in the arterial blood of six asthmatic patients. A total of 20 ml of blood was drawn from the femoral artery of the patients during remission and during wheezing attack under treatment without prednisolone. Leukotriene E 4 was detected by high pressure liquid chromatography and radioimmunoassay. In the six patients, mean LTE 4 levels were 12.5 ± 4.0 and 67.3 ± 17.6 pg/ml during remission and wheezing, respectively. In contrast, the mean LTE 4 level of six healthy control subjects was 10.8 ± 3.74 pg/ml. The LTE 4 levels during remission and during the wheezing attacks differed significantly ( P 1 values were 86.9 ± 3.9 and 43.5 ± 3.6. Thus LTE 4 was strongly correlated with FEV 1 . We conclude that LTE 4 levels in arterial blood reflect the severity of asthma attacks." @default.
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- W2000780057 date "1993-03-01" @default.
- W2000780057 modified "2023-09-27" @default.
- W2000780057 title "Relationship between plasma levels of leukotriene E4 and FEV1 in asthmatic patients" @default.
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- W2000780057 doi "https://doi.org/10.1016/s0011-393x(05)80787-8" @default.
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