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- W2000780459 abstract "Background: Phospholipids are known to cause matrix effects in LC–MS analysis and are not effectively removed by one of the most common method of sample preparation: organic solvent protein precipitation. The objective of this research is to minimize phospholipid interferences chromatographically. Results: In this article we examine several chromatographic approaches and highlight the method we developed that allows for the rapid gradient separation of model drug molecules from phospholipids. Conclusion: The new approach (which utilizes a mixture of methanol and acetonitrile as the organic mobile phase on a 2.1 × 20 mm C18 column) minimized phospholipids-related matrix effects in the analysis of plasma samples prepared by protein precipitation and is suitable for high-throughput bioanalysis in drug discovery." @default.
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- W2000780459 date "2011-07-01" @default.
- W2000780459 modified "2023-09-23" @default.
- W2000780459 title "Minimizing matrix effects while preserving throughput in LC–MS/MS bioanalysis" @default.
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- W2000780459 doi "https://doi.org/10.4155/bio.11.141" @default.
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