FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000780795> ?p ?o ?g. }

• W2000780795 endingPage "507" @default.
• W2000780795 startingPage "499" @default.
• W2000780795 abstract "We recently improved an in vitro ischemic model, using PC12 neuronal cultures exposed to oxygen-glucose deprivation (OGD) for 3 hr in a special device, followed by 18 hr of reoxygenation. The cell death induced in this ischemic model was evaluated by a series of markers: lactate dehydrogenase (LDH) release, caspase-3 activation, presence of cyclin D1, cytochrome c leakage from the mitochondria, BAX cellular redistribution, cleavage of poly (ADP-ribose) polymerase (PARP) to an 85-kDa apoptotic fragment, and DNA fragmentation. The OGD insult, in the absence of reoxygenation, caused a strong activation of the mitogen-activated protein kinase (MAPK) isoforms extracellular regulated kinase (ERK), c-Jun NH2-terminal kinase (JNK), and stress-activated protein kinase (SAPK), also known as p-38. The detection of apoptotic markers and activation of MAPKs during the ischemic insult strongly suggest that apoptosis plays an important role in the PC12 cell death. Homocarnosine, a neuroprotective histidine dipeptide, present in high concentrations in the brain, was found to provide neuroprotection, as expressed by a 40% reduction in LDH release and caspase-3 activity at 1 mM. Homocarnosine reduced OGD activation of ERK 1, ERK 2, JNK 1, and JNK 2 by 40%, 46%, 55%, and 30%, respectively. These results suggest that apoptosis is an important characteristic of OGD-induced neuronal death and that antioxidants, such as homocarnosine, may prevent OGD-induced neuronal death by inhibiting the apoptotic process and/or in relation to the differential attenuation of activity of MAPKs." @default.
• W2000780795 created "2016-06-24" @default.
• W2000780795 creator A5033243780 @default.
• W2000780795 creator A5049332135 @default.
• W2000780795 creator A5053182759 @default.
• W2000780795 creator A5063592070 @default.
• W2000780795 creator A5072325478 @default.
• W2000780795 date "2004-01-13" @default.
• W2000780795 modified "2023-10-15" @default.
• W2000780795 title "Apoptotic characteristics of cell death and the neuroprotective effect of homocarnosine on pheochromocytoma PC12 cells exposed to ischemia" @default.
• W2000780795 cites W136179538 @default.
• W2000780795 cites W1515821225 @default.
• W2000780795 cites W1517407659 @default.
• W2000780795 cites W1572605366 @default.
• W2000780795 cites W1591176056 @default.
• W2000780795 cites W1603686013 @default.
• W2000780795 cites W1631361623 @default.
• W2000780795 cites W1734090629 @default.
• W2000780795 cites W1788426598 @default.
• W2000780795 cites W1984715375 @default.
• W2000780795 cites W1986483742 @default.
• W2000780795 cites W1991274073 @default.
• W2000780795 cites W1994682771 @default.
• W2000780795 cites W1994930616 @default.
• W2000780795 cites W1996886208 @default.
• W2000780795 cites W2003030097 @default.
• W2000780795 cites W2009730569 @default.
• W2000780795 cites W2017813077 @default.
• W2000780795 cites W2021567803 @default.
• W2000780795 cites W2022484858 @default.
• W2000780795 cites W2031398528 @default.
• W2000780795 cites W2031702150 @default.
• W2000780795 cites W2036529420 @default.
• W2000780795 cites W2038778351 @default.
• W2000780795 cites W2039450652 @default.
• W2000780795 cites W2052318954 @default.
• W2000780795 cites W2056956879 @default.
• W2000780795 cites W2057199729 @default.
• W2000780795 cites W2060963131 @default.
• W2000780795 cites W2065572121 @default.
• W2000780795 cites W2068953709 @default.
• W2000780795 cites W2082372926 @default.
• W2000780795 cites W2085031640 @default.
• W2000780795 cites W2090799728 @default.
• W2000780795 cites W2091463654 @default.
• W2000780795 cites W2108233949 @default.
• W2000780795 cites W2113686815 @default.
• W2000780795 cites W2116951446 @default.
• W2000780795 cites W2117895323 @default.
• W2000780795 cites W2122057254 @default.
• W2000780795 cites W2133414832 @default.
• W2000780795 cites W2139922386 @default.
• W2000780795 cites W2141020349 @default.
• W2000780795 cites W2153374859 @default.
• W2000780795 cites W2155124532 @default.
• W2000780795 cites W2241961120 @default.
• W2000780795 cites W4252003723 @default.
• W2000780795 cites W4293247451 @default.
• W2000780795 cites W71702394 @default.
• W2000780795 doi "https://doi.org/10.1002/jnr.20008" @default.
• W2000780795 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14743433" @default.
• W2000780795 hasPublicationYear "2004" @default.
• W2000780795 type Work @default.
• W2000780795 sameAs 2000780795 @default.
• W2000780795 citedByCount "43" @default.
• W2000780795 countsByYear W20007807952012 @default.
• W2000780795 countsByYear W20007807952013 @default.
• W2000780795 countsByYear W20007807952014 @default.
• W2000780795 countsByYear W20007807952015 @default.
• W2000780795 countsByYear W20007807952016 @default.
• W2000780795 countsByYear W20007807952017 @default.
• W2000780795 countsByYear W20007807952018 @default.
• W2000780795 countsByYear W20007807952019 @default.
• W2000780795 countsByYear W20007807952020 @default.
• W2000780795 crossrefType "journal-article" @default.
• W2000780795 hasAuthorship W2000780795A5033243780 @default.
• W2000780795 hasAuthorship W2000780795A5049332135 @default.
• W2000780795 hasAuthorship W2000780795A5053182759 @default.
• W2000780795 hasAuthorship W2000780795A5063592070 @default.
• W2000780795 hasAuthorship W2000780795A5072325478 @default.
• W2000780795 hasConcept C153911025 @default.
• W2000780795 hasConcept C184235292 @default.
• W2000780795 hasConcept C190283241 @default.
• W2000780795 hasConcept C25498285 @default.
• W2000780795 hasConcept C29311851 @default.
• W2000780795 hasConcept C31573885 @default.
• W2000780795 hasConcept C43759708 @default.
• W2000780795 hasConcept C55493867 @default.
• W2000780795 hasConcept C57074206 @default.
• W2000780795 hasConcept C86803240 @default.
• W2000780795 hasConcept C95444343 @default.
• W2000780795 hasConcept C97029542 @default.
• W2000780795 hasConcept C98274493 @default.
• W2000780795 hasConceptScore W2000780795C153911025 @default.
• W2000780795 hasConceptScore W2000780795C184235292 @default.
• W2000780795 hasConceptScore W2000780795C190283241 @default.
• W2000780795 hasConceptScore W2000780795C25498285 @default.
• W2000780795 hasConceptScore W2000780795C29311851 @default.

• next