Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000781585> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2000781585 abstract "We reviewed 34 patients with histologically proven anaplastic thyroid carcinoma, representing 3.1% of all thyroid carcinomas treated from 1970 to 1992 in our Institution. Mean age at diagnosis was 63.1+/-10.3 years. Initial treatment consisted of near total thyroidectomy in 14 patients, partial thyroidectomy in 6 and no more than a biopsy in 14. After surgery 11 patients received external radiotherapy associated with chemotherapy (R+C), 8 patients had only chemotherapy (C), and 11 patients had only radiotherapy (R). Two patients, both in the group treated with R+C, are still alive, with a survival from the diagnosis of 23 and 26 months, respectively. Mean survival of the group treated with R+C (16.1+/-8.2 months) was significantly higher than that of patients treated only with C (6.2+/-4.4 months; p<0.01) or only with R (5.1+/-2.6 months; p<0.0004). In the group treated with R+C, patients submitted to near total or partial thyroidectomy had a mean survival of 15.0+/-8.8 months, similar to that of patients who had only a biopsy (17.2+/-7.9 months), suggesting that the outcome was affected by post-surgical therapy rather than by surgery per se. Twenty-two tumors were also assayed by immunohistochemistry for p53 and PCNA expression. p53 was expressed in 16/22 (72.2%) cases, with no correlation with sex, age, presence of differentiated component or survival. Comparing tumors with <30% or >30% p53 positive cells a tendency to longer (but not significant) survival was found in tumors with lower p53 expression. PCNA was expressed in all cases, with a percentage of positive cells ranging from 15% to 90%, and was not correlated with sex, age, differentiation, or survival. A positive correlation was found between PCNA and p53 expression (r=0.58; p=0.0039). In conclusion, our data indicate that in anaplastic thyroid carcinoma the use of combined R+C has some advantages with respect to single therapy. As in other aggressive malignancies; p53 and PCNA expression is increased irrespective of the response to therapy or the outcome." @default.
- W2000781585 created "2016-06-24" @default.
- W2000781585 creator A5007145631 @default.
- W2000781585 creator A5010347660 @default.
- W2000781585 creator A5014279456 @default.
- W2000781585 creator A5017474339 @default.
- W2000781585 creator A5019570497 @default.
- W2000781585 creator A5024881552 @default.
- W2000781585 creator A5036079877 @default.
- W2000781585 creator A5060902293 @default.
- W2000781585 creator A5083770629 @default.
- W2000781585 date "1994-09-01" @default.
- W2000781585 modified "2023-09-27" @default.
- W2000781585 title "ANAPLASTIC THYROID-CARCINOMA - A RETROSPECTIVE CLINICAL AND IMMUNOHISTOCHEMICAL STUDY" @default.
- W2000781585 doi "https://doi.org/10.3892/or.1.5.921" @default.
- W2000781585 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21607467" @default.
- W2000781585 hasPublicationYear "1994" @default.
- W2000781585 type Work @default.
- W2000781585 sameAs 2000781585 @default.
- W2000781585 citedByCount "4" @default.
- W2000781585 countsByYear W20007815852022 @default.
- W2000781585 crossrefType "journal-article" @default.
- W2000781585 hasAuthorship W2000781585A5007145631 @default.
- W2000781585 hasAuthorship W2000781585A5010347660 @default.
- W2000781585 hasAuthorship W2000781585A5014279456 @default.
- W2000781585 hasAuthorship W2000781585A5017474339 @default.
- W2000781585 hasAuthorship W2000781585A5019570497 @default.
- W2000781585 hasAuthorship W2000781585A5024881552 @default.
- W2000781585 hasAuthorship W2000781585A5036079877 @default.
- W2000781585 hasAuthorship W2000781585A5060902293 @default.
- W2000781585 hasAuthorship W2000781585A5083770629 @default.
- W2000781585 hasConcept C121608353 @default.
- W2000781585 hasConcept C126322002 @default.
- W2000781585 hasConcept C142724271 @default.
- W2000781585 hasConcept C143998085 @default.
- W2000781585 hasConcept C204232928 @default.
- W2000781585 hasConcept C2775934546 @default.
- W2000781585 hasConcept C2776694085 @default.
- W2000781585 hasConcept C2777074255 @default.
- W2000781585 hasConcept C2777546739 @default.
- W2000781585 hasConcept C2778981773 @default.
- W2000781585 hasConcept C2781018059 @default.
- W2000781585 hasConcept C29537977 @default.
- W2000781585 hasConcept C2993294228 @default.
- W2000781585 hasConcept C34688535 @default.
- W2000781585 hasConcept C509974204 @default.
- W2000781585 hasConcept C526584372 @default.
- W2000781585 hasConcept C67082663 @default.
- W2000781585 hasConcept C71924100 @default.
- W2000781585 hasConcept C90924648 @default.
- W2000781585 hasConceptScore W2000781585C121608353 @default.
- W2000781585 hasConceptScore W2000781585C126322002 @default.
- W2000781585 hasConceptScore W2000781585C142724271 @default.
- W2000781585 hasConceptScore W2000781585C143998085 @default.
- W2000781585 hasConceptScore W2000781585C204232928 @default.
- W2000781585 hasConceptScore W2000781585C2775934546 @default.
- W2000781585 hasConceptScore W2000781585C2776694085 @default.
- W2000781585 hasConceptScore W2000781585C2777074255 @default.
- W2000781585 hasConceptScore W2000781585C2777546739 @default.
- W2000781585 hasConceptScore W2000781585C2778981773 @default.
- W2000781585 hasConceptScore W2000781585C2781018059 @default.
- W2000781585 hasConceptScore W2000781585C29537977 @default.
- W2000781585 hasConceptScore W2000781585C2993294228 @default.
- W2000781585 hasConceptScore W2000781585C34688535 @default.
- W2000781585 hasConceptScore W2000781585C509974204 @default.
- W2000781585 hasConceptScore W2000781585C526584372 @default.
- W2000781585 hasConceptScore W2000781585C67082663 @default.
- W2000781585 hasConceptScore W2000781585C71924100 @default.
- W2000781585 hasConceptScore W2000781585C90924648 @default.
- W2000781585 hasLocation W20007815851 @default.
- W2000781585 hasLocation W20007815852 @default.
- W2000781585 hasOpenAccess W2000781585 @default.
- W2000781585 hasPrimaryLocation W20007815851 @default.
- W2000781585 hasRelatedWork W1487435673 @default.
- W2000781585 hasRelatedWork W2020859152 @default.
- W2000781585 hasRelatedWork W2040962112 @default.
- W2000781585 hasRelatedWork W2050370170 @default.
- W2000781585 hasRelatedWork W2077120161 @default.
- W2000781585 hasRelatedWork W2079145144 @default.
- W2000781585 hasRelatedWork W2086677620 @default.
- W2000781585 hasRelatedWork W2095362661 @default.
- W2000781585 hasRelatedWork W2115372159 @default.
- W2000781585 hasRelatedWork W2117267632 @default.
- W2000781585 hasRelatedWork W2286002044 @default.
- W2000781585 hasRelatedWork W2331075080 @default.
- W2000781585 hasRelatedWork W2385340735 @default.
- W2000781585 hasRelatedWork W2418501833 @default.
- W2000781585 hasRelatedWork W2443438865 @default.
- W2000781585 hasRelatedWork W2443820485 @default.
- W2000781585 hasRelatedWork W2512635665 @default.
- W2000781585 hasRelatedWork W273867889 @default.
- W2000781585 hasRelatedWork W2977730512 @default.
- W2000781585 hasRelatedWork W3141069823 @default.
- W2000781585 isParatext "false" @default.
- W2000781585 isRetracted "false" @default.
- W2000781585 magId "2000781585" @default.
- W2000781585 workType "article" @default.