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- W2000783260 abstract "The intracellular toll/interleukin-1 receptor (TIR) domain plays an important role in vertebrate immunity, but the evolution and function of invertebrate TIR-domain-containing proteins is not fully understood. This study characterized and compared the TIR-domain-containing protein repertoire of nine cnidarians in class Anthozoa. A diverse set of proteins, including MyD88 (myeloid differentiation primary response protein 88), toll-like receptor (TLR)-like, interleukin-1 receptor (IL-1R)-like, and TIR-only proteins are present in the species surveyed. Increased numbers of TIR-only proteins were observed in corals compared to anemones, especially in the Acroporid and Pocilloporid coral families. This expansion could be linked to diversity of the microbial community on or in hosts and managing both positive and negative associations. Phylogenetic analysis indicates there are two groups of proteins with IL-1R-like domain architecture in anthozoans that potentially evolved independently of the vertebrate family. Bacterial-like TIR_2 domain proteins are also present, including one sequence with novel domain architecture. Overall this work promotes a better understanding of the anthozoan immune repertoire, which is important in the context learning about ancestral immune pathways and host–microbe interactions." @default.
- W2000783260 created "2016-06-24" @default.
- W2000783260 creator A5076315642 @default.
- W2000783260 creator A5087871575 @default.
- W2000783260 date "2014-10-01" @default.
- W2000783260 modified "2023-09-23" @default.
- W2000783260 title "TIR-domain-containing protein repertoire of nine anthozoan species reveals coral–specific expansions and uncharacterized proteins" @default.
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- W2000783260 doi "https://doi.org/10.1016/j.dci.2014.06.002" @default.
- W2000783260 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24933613" @default.
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