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- W2000784355 abstract "The fate of [14C]tetrachlorodibenzofuran (TCDF) was studied in male Rhesus monkeys (Macaca mulatta) after a single iv treatment. Excretion was followed for 21 days post-treatment, and terminal distribution and toxicopathologic studies performed. After 3 weeks, less than 10% of the total dose of 30.7 μg/kg remained in the body. Both the urine and feces served as routes of excretion, with approximately four times more radioactivity being excreted via the fecal than the urinary route. The fat, skin, and liver were the major depots for the [14C]TCDF remaining in the body at 21 days. With the exception of traces of TCDF metabolites in the blood at 21 days, the radioactivity present in the body was parent compound, while radioactivity excreted from the body was in the form of metabolites of [14C]TCDF. Gross morphological alterations were noted in the eyelids of the monkeys at the time of sacrifice. Histopathological changes were detected in the Meibomian glands of the eyelid, the ceruminous glands of the external auditory canal, and in the epithelium of the stomach. Thus, although the disposition of TCDF in monkeys is similar to that previously reported for rats, monkeys clear TCDF from the body more slowly than do rats and are apparently more sensitive to TCDF intoxication." @default.
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- W2000784355 date "1981-02-01" @default.
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- W2000784355 title "Fate of 2,3,7,8-tetrachlorodibenzofuran in the monkey" @default.
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- W2000784355 doi "https://doi.org/10.1016/0041-008x(81)90279-9" @default.
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