Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000785482> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2000785482 endingPage "188" @default.
- W2000785482 startingPage "188" @default.
- W2000785482 abstract "This study sought to evaluate a 99mTc-labeled trimeric cyclic RGD peptide (99mTc-4P-RGD3) as the new radiotracer for tumor imaging. The objective was to compare its biological properties with those of 99mTc-3P-RGD2 in the same animal model.HYNIC-4P-RGD3 was prepared by reacting 4P-RGD3 with excess HYNIC-OSu in the presence of diisopropylethylamine. 99mTc-4P-RGD3 was prepared using a kit formulation, and evaluated for its tumor-targeting capability and biodistribution properties in the BALB/c nude mice with U87MG human glioma xenografts. Planar and SPECT imaging studies were performed in athymic nude mice with U87MG glioma xenografts. For comparison purpose, 99mTc-3P-RGD2 (a αvβ3-targeted radiotracer currently under clinical evaluation for tumor imaging in cancer patients) was also evaluated in the same animal models. Blocking experiments were used to demonstrate the αvβ3 specificity of 99mTc-4P-RGD3.99mTc-4P-RGD3 was prepared with > 95% RCP and high specific activity (~ 200 GBq/μmol). 99mTc-4P-RGD3 and 99mTc-3P-RGD2 shared almost identical tumor uptake and similar biodistribution properties. 99mTc-4P-RGD3 had higher uptake than 99mTc-3P-RGD2 in the intestines and kidneys; but it showed better metabolic stability. The U87MG tumors were clearly visualized by SPECT with excellent contrast with 99mTc-4P-RGD3 and 99mTc-3P-RGD2.Increasing peptide multiplicity from 3P-RGD2 to 4P-RGD3 offers no advantages with respect to the tumor-targeting capability. 99mTc-4P-RGD3 is as good a SPECT radiotracer as 99mTc-3P-RGD2 for imaging αvβ3-positive tumors." @default.
- W2000785482 created "2016-06-24" @default.
- W2000785482 creator A5003744229 @default.
- W2000785482 creator A5032293215 @default.
- W2000785482 creator A5038177916 @default.
- W2000785482 creator A5039336636 @default.
- W2000785482 creator A5041491201 @default.
- W2000785482 creator A5046734565 @default.
- W2000785482 creator A5073189087 @default.
- W2000785482 creator A5080564883 @default.
- W2000785482 creator A5082938072 @default.
- W2000785482 creator A5087951266 @default.
- W2000785482 date "2010-11-01" @default.
- W2000785482 modified "2023-09-26" @default.
- W2000785482 title "599 Antiangiogenic effects of linifanib (ABT-869) in xenograft models and patients with solid tumors" @default.
- W2000785482 doi "https://doi.org/10.1016/s1359-6349(10)72306-5" @default.
- W2000785482 hasPublicationYear "2010" @default.
- W2000785482 type Work @default.
- W2000785482 sameAs 2000785482 @default.
- W2000785482 citedByCount "0" @default.
- W2000785482 crossrefType "journal-article" @default.
- W2000785482 hasAuthorship W2000785482A5003744229 @default.
- W2000785482 hasAuthorship W2000785482A5032293215 @default.
- W2000785482 hasAuthorship W2000785482A5038177916 @default.
- W2000785482 hasAuthorship W2000785482A5039336636 @default.
- W2000785482 hasAuthorship W2000785482A5041491201 @default.
- W2000785482 hasAuthorship W2000785482A5046734565 @default.
- W2000785482 hasAuthorship W2000785482A5073189087 @default.
- W2000785482 hasAuthorship W2000785482A5080564883 @default.
- W2000785482 hasAuthorship W2000785482A5082938072 @default.
- W2000785482 hasAuthorship W2000785482A5087951266 @default.
- W2000785482 hasConcept C121608353 @default.
- W2000785482 hasConcept C126322002 @default.
- W2000785482 hasConcept C185592680 @default.
- W2000785482 hasConcept C202751555 @default.
- W2000785482 hasConcept C2777807558 @default.
- W2000785482 hasConcept C2778117688 @default.
- W2000785482 hasConcept C2989005 @default.
- W2000785482 hasConcept C2994114330 @default.
- W2000785482 hasConcept C502942594 @default.
- W2000785482 hasConcept C55493867 @default.
- W2000785482 hasConcept C71924100 @default.
- W2000785482 hasConceptScore W2000785482C121608353 @default.
- W2000785482 hasConceptScore W2000785482C126322002 @default.
- W2000785482 hasConceptScore W2000785482C185592680 @default.
- W2000785482 hasConceptScore W2000785482C202751555 @default.
- W2000785482 hasConceptScore W2000785482C2777807558 @default.
- W2000785482 hasConceptScore W2000785482C2778117688 @default.
- W2000785482 hasConceptScore W2000785482C2989005 @default.
- W2000785482 hasConceptScore W2000785482C2994114330 @default.
- W2000785482 hasConceptScore W2000785482C502942594 @default.
- W2000785482 hasConceptScore W2000785482C55493867 @default.
- W2000785482 hasConceptScore W2000785482C71924100 @default.
- W2000785482 hasIssue "7" @default.
- W2000785482 hasLocation W20007854821 @default.
- W2000785482 hasOpenAccess W2000785482 @default.
- W2000785482 hasPrimaryLocation W20007854821 @default.
- W2000785482 hasRelatedWork W1987262526 @default.
- W2000785482 hasRelatedWork W2266680082 @default.
- W2000785482 hasRelatedWork W2365364931 @default.
- W2000785482 hasRelatedWork W2418638721 @default.
- W2000785482 hasRelatedWork W2421284360 @default.
- W2000785482 hasRelatedWork W2748952813 @default.
- W2000785482 hasRelatedWork W2807632826 @default.
- W2000785482 hasRelatedWork W2885376240 @default.
- W2000785482 hasRelatedWork W2899084033 @default.
- W2000785482 hasRelatedWork W3171817577 @default.
- W2000785482 hasVolume "8" @default.
- W2000785482 isParatext "false" @default.
- W2000785482 isRetracted "false" @default.
- W2000785482 magId "2000785482" @default.
- W2000785482 workType "article" @default.