FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000786327> ?p ?o ?g. }

• W2000786327 endingPage "463" @default.
• W2000786327 startingPage "455" @default.
• W2000786327 abstract "In a screening for new inhibitors of NF-κB and AP-1 mediated signal transduction pathways in COS-7 cells using secreted alkaline phosphatase (SEAP) as a reporter gene three novel compounds, cycloepoxydon (1), 1-hydroxy-2-hydroxymethyl-3-pent-1-enylbenzene (2) and 1-hydroxy-2-hydroxymethyl-3-pent-1, 3-dienylbenzene (3) were isolated from fermentations of the deuteromycete strain 45—93. Cycloepoxydon inhibits the TPA-induced NF-κB and AP-1 mediated SEAP expression with an IC50 of 1∼2 μg/ml (4.2∼8.4 μM) and 3∼5 μg/ml (12.6∼21 μM) respectively. 1-Hydroxy-2-hydroxymethyl-3-pent-1-enylbenzene (2) inhibits the TPA-induced NF-κB and AP-1 mediated SEAP expression with an IC50 of 7 μg/ml (36.4 μM) and 5 μg/ml (26 μM). 3 showed only a weak inhibition of the AP-1 and no influence on NF-κB dependent reporter gene expression. In COS-7 and HeLa S3 cells electrophoretic mobility shift assays showed that cycloepoxydon strongly reduced the TPA and TNF-α mediated binding of NF-κB to a high affinity consensus sequence which was due to the inhibition of phosphorylation of the inhibitory protein IκB." @default.
• W2000786327 created "2016-06-24" @default.
• W2000786327 creator A5011961568 @default.
• W2000786327 creator A5024499741 @default.
• W2000786327 creator A5054558559 @default.
• W2000786327 creator A5076822722 @default.
• W2000786327 date "1998-01-01" @default.
• W2000786327 modified "2023-10-01" @default.
• W2000786327 title "Cycloepoxydon, 1-Hydroxy-2 hydroxymethyl-3-pent-1-enylbenzene and 1-Hydroxy-2-hydroxymethyl-3-pent-1,3-dienylbenzene, New Inhibitors of Eukaryotic Signal Transduction." @default.
• W2000786327 cites W1274973028 @default.
• W2000786327 cites W1516457342 @default.
• W2000786327 cites W1577403013 @default.
• W2000786327 cites W1969494970 @default.
• W2000786327 cites W1970872426 @default.
• W2000786327 cites W1979520552 @default.
• W2000786327 cites W1987453246 @default.
• W2000786327 cites W2004141049 @default.
• W2000786327 cites W2016523675 @default.
• W2000786327 cites W2045515718 @default.
• W2000786327 cites W2047263793 @default.
• W2000786327 cites W2056831005 @default.
• W2000786327 cites W2059142621 @default.
• W2000786327 cites W2069261043 @default.
• W2000786327 cites W2085635715 @default.
• W2000786327 cites W2096665268 @default.
• W2000786327 cites W2116937468 @default.
• W2000786327 cites W2118897660 @default.
• W2000786327 cites W2150033965 @default.
• W2000786327 cites W2151892297 @default.
• W2000786327 cites W2166781237 @default.
• W2000786327 cites W2312657304 @default.
• W2000786327 cites W37351408 @default.
• W2000786327 cites W43967522 @default.
• W2000786327 cites W618247855 @default.
• W2000786327 doi "https://doi.org/10.7164/antibiotics.51.455" @default.
• W2000786327 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9666173" @default.
• W2000786327 hasPublicationYear "1998" @default.
• W2000786327 type Work @default.
• W2000786327 sameAs 2000786327 @default.
• W2000786327 citedByCount "54" @default.
• W2000786327 countsByYear W20007863272012 @default.
• W2000786327 countsByYear W20007863272013 @default.
• W2000786327 countsByYear W20007863272014 @default.
• W2000786327 countsByYear W20007863272015 @default.
• W2000786327 countsByYear W20007863272017 @default.
• W2000786327 countsByYear W20007863272018 @default.
• W2000786327 countsByYear W20007863272019 @default.
• W2000786327 countsByYear W20007863272020 @default.
• W2000786327 countsByYear W20007863272021 @default.
• W2000786327 crossrefType "journal-article" @default.
• W2000786327 hasAuthorship W2000786327A5011961568 @default.
• W2000786327 hasAuthorship W2000786327A5024499741 @default.
• W2000786327 hasAuthorship W2000786327A5054558559 @default.
• W2000786327 hasAuthorship W2000786327A5076822722 @default.
• W2000786327 hasBestOaLocation W20007863271 @default.
• W2000786327 hasConcept C104317684 @default.
• W2000786327 hasConcept C11960822 @default.
• W2000786327 hasConcept C150194340 @default.
• W2000786327 hasConcept C153911025 @default.
• W2000786327 hasConcept C160160445 @default.
• W2000786327 hasConcept C161733203 @default.
• W2000786327 hasConcept C178666793 @default.
• W2000786327 hasConcept C181199279 @default.
• W2000786327 hasConcept C185592680 @default.
• W2000786327 hasConcept C202751555 @default.
• W2000786327 hasConcept C2777366897 @default.
• W2000786327 hasConcept C2777752497 @default.
• W2000786327 hasConcept C2780591741 @default.
• W2000786327 hasConcept C55493867 @default.
• W2000786327 hasConcept C62478195 @default.
• W2000786327 hasConcept C71240020 @default.
• W2000786327 hasConcept C86803240 @default.
• W2000786327 hasConceptScore W2000786327C104317684 @default.
• W2000786327 hasConceptScore W2000786327C11960822 @default.
• W2000786327 hasConceptScore W2000786327C150194340 @default.
• W2000786327 hasConceptScore W2000786327C153911025 @default.
• W2000786327 hasConceptScore W2000786327C160160445 @default.
• W2000786327 hasConceptScore W2000786327C161733203 @default.
• W2000786327 hasConceptScore W2000786327C178666793 @default.
• W2000786327 hasConceptScore W2000786327C181199279 @default.
• W2000786327 hasConceptScore W2000786327C185592680 @default.
• W2000786327 hasConceptScore W2000786327C202751555 @default.
• W2000786327 hasConceptScore W2000786327C2777366897 @default.
• W2000786327 hasConceptScore W2000786327C2777752497 @default.
• W2000786327 hasConceptScore W2000786327C2780591741 @default.
• W2000786327 hasConceptScore W2000786327C55493867 @default.
• W2000786327 hasConceptScore W2000786327C62478195 @default.
• W2000786327 hasConceptScore W2000786327C71240020 @default.
• W2000786327 hasConceptScore W2000786327C86803240 @default.
• W2000786327 hasIssue "5" @default.
• W2000786327 hasLocation W20007863271 @default.
• W2000786327 hasLocation W20007863272 @default.
• W2000786327 hasOpenAccess W2000786327 @default.
• W2000786327 hasPrimaryLocation W20007863271 @default.
• W2000786327 hasRelatedWork W1978495037 @default.
• W2000786327 hasRelatedWork W1984563867 @default.
• W2000786327 hasRelatedWork W1995690959 @default.
• W2000786327 hasRelatedWork W1996142715 @default.

• next