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- W2000786512 abstract "We have isolated mutations in the gene encoding a Drosophila 14-3-3 epsilon protein as suppressors of the rough eye phenotype caused by the ectopic expression of RAS1(V12). Using a simple loss-of-function 14-3-3 epsilon mutation, we show that 14-3-3 epsilon acts to increase the efficiency of RAS1 signaling. The 14-3-3 epsilon protein appears to function in multiple RTK pathways, suggesting that it is a general component of RAS1 signaling cascade. Sequence analysis of three dominant-negative alleles defines two regions of 14-3-3 epsilon that participate in RAS1 signaling. We also present evidence that 14-3-3 epsilon and 14-3-3 zeta, two 14-3-3 protein family members, are partially redundant for RAS1 signaling in photoreceptor formation and in animal viability. Our genetic data suggest that 14-3-3 epsilon functions downstream of or parallel to RAF, but upstream of nuclear factors in RAS1 signaling." @default.
- W2000786512 created "2016-06-24" @default.
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- W2000786512 date "1997-05-01" @default.
- W2000786512 modified "2023-10-18" @default.
- W2000786512 title "14-3-3 epsilon positively regulates Ras-mediated signaling in Drosophila." @default.
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- W2000786512 doi "https://doi.org/10.1101/gad.11.9.1132" @default.
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