FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000786789> ?p ?o ?g. }

• W2000786789 endingPage "450" @default.
• W2000786789 startingPage "443" @default.
• W2000786789 abstract "The gelatinases B (MMP9) and A (MMP2) are two members of the matrix metalloproteinase (MMPs) family that are expressed in human cancer, and play a critical role in tumor cell invasion and metastasis. Caveolin-1 (Cav1) has recently been identified as a tumor metastasis modifier gene. However, the effect and mechanism of Cav1 in pancreatic carcinoma cell invasion remain unknown. In this study, we investigated the expression of Cav1, MMP2, and MMP9 in several different pancreatic carcinoma cell lines. We transfected pcDNA3.0-Cav1 plasmid and Cav1 siRNA into SW1990 and Bxpc3 cells, respectively. Using cell invasion assay, we found that overexpression of Cav1 inhibited cell invasion, whereas the knockdown of Cav1 in Bxpc3 cells promoted cell invasion. Moreover, to explore the mechanisms underlying these observations, we further investigated the expression of MMP2, MMP9, phospho-Akt, and phospho-Erk by Western blot, and the activities of MMP2 and MMP9 by gelatin zymography. The results indicated that Cav1 gene could inhibit pancreatic carcinoma cell invasion, at least in part, probably through Erk-MMP signal pathway, suggesting that the endogenous expression or re-expression of Cav1 might help therapeutically reduce their invasive potential in pancreatic carcinoma cells. The gelatinases B (MMP9) and A (MMP2) are two members of the matrix metalloproteinase (MMPs) family that are expressed in human cancer, and play a critical role in tumor cell invasion and metastasis. Caveolin-1 (Cav1) has recently been identified as a tumor metastasis modifier gene. However, the effect and mechanism of Cav1 in pancreatic carcinoma cell invasion remain unknown. In this study, we investigated the expression of Cav1, MMP2, and MMP9 in several different pancreatic carcinoma cell lines. We transfected pcDNA3.0-Cav1 plasmid and Cav1 siRNA into SW1990 and Bxpc3 cells, respectively. Using cell invasion assay, we found that overexpression of Cav1 inhibited cell invasion, whereas the knockdown of Cav1 in Bxpc3 cells promoted cell invasion. Moreover, to explore the mechanisms underlying these observations, we further investigated the expression of MMP2, MMP9, phospho-Akt, and phospho-Erk by Western blot, and the activities of MMP2 and MMP9 by gelatin zymography. The results indicated that Cav1 gene could inhibit pancreatic carcinoma cell invasion, at least in part, probably through Erk-MMP signal pathway, suggesting that the endogenous expression or re-expression of Cav1 might help therapeutically reduce their invasive potential in pancreatic carcinoma cells." @default.
• W2000786789 created "2016-06-24" @default.
• W2000786789 creator A5000952365 @default.
• W2000786789 creator A5090937408 @default.
• W2000786789 date "2010-03-01" @default.
• W2000786789 modified "2023-09-27" @default.
• W2000786789 title "Caveolin-1 Regulating the Invasion and Expression of Matrix Metalloproteinase (MMPs) in Pancreatic Carcinoma Cells" @default.
• W2000786789 cites W1898291621 @default.
• W2000786789 cites W1967244662 @default.
• W2000786789 cites W1968905163 @default.
• W2000786789 cites W1975322467 @default.
• W2000786789 cites W1977049975 @default.
• W2000786789 cites W2000082154 @default.
• W2000786789 cites W2001793094 @default.
• W2000786789 cites W2013539224 @default.
• W2000786789 cites W2020166810 @default.
• W2000786789 cites W2023284036 @default.
• W2000786789 cites W2034464608 @default.
• W2000786789 cites W2049571580 @default.
• W2000786789 cites W2065666236 @default.
• W2000786789 cites W2075542566 @default.
• W2000786789 cites W2087222747 @default.
• W2000786789 cites W2087792023 @default.
• W2000786789 cites W2094641853 @default.
• W2000786789 cites W2103918128 @default.
• W2000786789 cites W2105893914 @default.
• W2000786789 cites W2106146395 @default.
• W2000786789 cites W2148880541 @default.
• W2000786789 cites W2172064884 @default.
• W2000786789 cites W2331524250 @default.
• W2000786789 cites W4244794328 @default.
• W2000786789 cites W912507531 @default.
• W2000786789 doi "https://doi.org/10.1016/j.jss.2009.03.079" @default.
• W2000786789 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20031158" @default.
• W2000786789 hasPublicationYear "2010" @default.
• W2000786789 type Work @default.
• W2000786789 sameAs 2000786789 @default.
• W2000786789 citedByCount "47" @default.
• W2000786789 countsByYear W20007867892012 @default.
• W2000786789 countsByYear W20007867892013 @default.
• W2000786789 countsByYear W20007867892014 @default.
• W2000786789 countsByYear W20007867892015 @default.
• W2000786789 countsByYear W20007867892016 @default.
• W2000786789 countsByYear W20007867892017 @default.
• W2000786789 countsByYear W20007867892018 @default.
• W2000786789 countsByYear W20007867892019 @default.
• W2000786789 countsByYear W20007867892023 @default.
• W2000786789 crossrefType "journal-article" @default.
• W2000786789 hasAuthorship W2000786789A5000952365 @default.
• W2000786789 hasAuthorship W2000786789A5090937408 @default.
• W2000786789 hasConcept C104317684 @default.
• W2000786789 hasConcept C109523444 @default.
• W2000786789 hasConcept C121608353 @default.
• W2000786789 hasConcept C127561419 @default.
• W2000786789 hasConcept C137738243 @default.
• W2000786789 hasConcept C173396325 @default.
• W2000786789 hasConcept C2775997469 @default.
• W2000786789 hasConcept C2776232661 @default.
• W2000786789 hasConcept C2779013556 @default.
• W2000786789 hasConcept C2780210213 @default.
• W2000786789 hasConcept C2780699576 @default.
• W2000786789 hasConcept C502942594 @default.
• W2000786789 hasConcept C54009773 @default.
• W2000786789 hasConcept C54355233 @default.
• W2000786789 hasConcept C55493867 @default.
• W2000786789 hasConcept C81885089 @default.
• W2000786789 hasConcept C86803240 @default.
• W2000786789 hasConceptScore W2000786789C104317684 @default.
• W2000786789 hasConceptScore W2000786789C109523444 @default.
• W2000786789 hasConceptScore W2000786789C121608353 @default.
• W2000786789 hasConceptScore W2000786789C127561419 @default.
• W2000786789 hasConceptScore W2000786789C137738243 @default.
• W2000786789 hasConceptScore W2000786789C173396325 @default.
• W2000786789 hasConceptScore W2000786789C2775997469 @default.
• W2000786789 hasConceptScore W2000786789C2776232661 @default.
• W2000786789 hasConceptScore W2000786789C2779013556 @default.
• W2000786789 hasConceptScore W2000786789C2780210213 @default.
• W2000786789 hasConceptScore W2000786789C2780699576 @default.
• W2000786789 hasConceptScore W2000786789C502942594 @default.
• W2000786789 hasConceptScore W2000786789C54009773 @default.
• W2000786789 hasConceptScore W2000786789C54355233 @default.
• W2000786789 hasConceptScore W2000786789C55493867 @default.
• W2000786789 hasConceptScore W2000786789C81885089 @default.
• W2000786789 hasConceptScore W2000786789C86803240 @default.
• W2000786789 hasIssue "1" @default.
• W2000786789 hasLocation W20007867891 @default.
• W2000786789 hasLocation W20007867892 @default.
• W2000786789 hasOpenAccess W2000786789 @default.
• W2000786789 hasPrimaryLocation W20007867891 @default.
• W2000786789 hasRelatedWork W2074669451 @default.
• W2000786789 hasRelatedWork W2153539494 @default.
• W2000786789 hasRelatedWork W2188724532 @default.
• W2000786789 hasRelatedWork W219817571 @default.
• W2000786789 hasRelatedWork W2204191013 @default.
• W2000786789 hasRelatedWork W2337680646 @default.
• W2000786789 hasRelatedWork W2380666494 @default.
• W2000786789 hasRelatedWork W2600717990 @default.
• W2000786789 hasRelatedWork W2608949869 @default.

• next