Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000787023> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2000787023 endingPage "308" @default.
- W2000787023 startingPage "303" @default.
- W2000787023 abstract "The present studies were undertaken to explore the use of intracerebral microdialysis to measure brain adrenergic receptor activity in vivo using the efflux of cyclic adenosine monophosphate (cAMP) in the extracellular fluid as an index of receptor function. An initial study with brain slices showed that extracellular levels of cAMP were highly correlated with intracellular levels after noradrenergic receptor activation. Detectable levels of extracellular cAMP were obtained from microdialysis probes implanted in the frontal cortex. Stable levels (3.5 +/- 2.7 pmol/ml) were obtained between 1.5 and 7 h after implantation. Perfusion of probes with NE (10(-5) to 10(-3) M) led to dose-dependent increases in cAMP efflux. The response to NE was blocked by infusion of the beta-antagonist, timolol, indicating that it reflected beta-receptor activation. Similar responses were obtained at 2 and 24 h after implantation indicating that the responses were not affected by acute traumatic effects of implantation. The findings show that the microdialysis technique can be successfully applied to the in vivo study of central adrenoceptor function. This suggests that the in vivo measurement of second messengers by microdialysis will provide a valuable new neurochemical and neuropharmacological technique." @default.
- W2000787023 created "2016-06-24" @default.
- W2000787023 creator A5039035475 @default.
- W2000787023 creator A5076390754 @default.
- W2000787023 creator A5086917610 @default.
- W2000787023 date "1988-08-01" @default.
- W2000787023 modified "2023-10-16" @default.
- W2000787023 title "Use of microdialysis to measure brain noradrenergic receptor function in vivo" @default.
- W2000787023 cites W1775749144 @default.
- W2000787023 cites W1966176157 @default.
- W2000787023 cites W1975689869 @default.
- W2000787023 cites W1992362705 @default.
- W2000787023 cites W2004094484 @default.
- W2000787023 cites W2019932147 @default.
- W2000787023 cites W2033797998 @default.
- W2000787023 cites W2037161788 @default.
- W2000787023 cites W2091013812 @default.
- W2000787023 cites W2109322747 @default.
- W2000787023 cites W2119005153 @default.
- W2000787023 cites W2132194608 @default.
- W2000787023 cites W2145295139 @default.
- W2000787023 cites W45574617 @default.
- W2000787023 doi "https://doi.org/10.1016/0006-8993(88)90472-6" @default.
- W2000787023 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2850079" @default.
- W2000787023 hasPublicationYear "1988" @default.
- W2000787023 type Work @default.
- W2000787023 sameAs 2000787023 @default.
- W2000787023 citedByCount "48" @default.
- W2000787023 countsByYear W20007870232013 @default.
- W2000787023 countsByYear W20007870232014 @default.
- W2000787023 countsByYear W20007870232020 @default.
- W2000787023 crossrefType "journal-article" @default.
- W2000787023 hasAuthorship W2000787023A5039035475 @default.
- W2000787023 hasAuthorship W2000787023A5076390754 @default.
- W2000787023 hasAuthorship W2000787023A5086917610 @default.
- W2000787023 hasConcept C126322002 @default.
- W2000787023 hasConcept C134018914 @default.
- W2000787023 hasConcept C150903083 @default.
- W2000787023 hasConcept C170493617 @default.
- W2000787023 hasConcept C185592680 @default.
- W2000787023 hasConcept C207001950 @default.
- W2000787023 hasConcept C25876315 @default.
- W2000787023 hasConcept C2776668983 @default.
- W2000787023 hasConcept C2776885963 @default.
- W2000787023 hasConcept C2778122271 @default.
- W2000787023 hasConcept C28406088 @default.
- W2000787023 hasConcept C50156730 @default.
- W2000787023 hasConcept C55493867 @default.
- W2000787023 hasConcept C71924100 @default.
- W2000787023 hasConcept C79879829 @default.
- W2000787023 hasConcept C86803240 @default.
- W2000787023 hasConcept C98274493 @default.
- W2000787023 hasConceptScore W2000787023C126322002 @default.
- W2000787023 hasConceptScore W2000787023C134018914 @default.
- W2000787023 hasConceptScore W2000787023C150903083 @default.
- W2000787023 hasConceptScore W2000787023C170493617 @default.
- W2000787023 hasConceptScore W2000787023C185592680 @default.
- W2000787023 hasConceptScore W2000787023C207001950 @default.
- W2000787023 hasConceptScore W2000787023C25876315 @default.
- W2000787023 hasConceptScore W2000787023C2776668983 @default.
- W2000787023 hasConceptScore W2000787023C2776885963 @default.
- W2000787023 hasConceptScore W2000787023C2778122271 @default.
- W2000787023 hasConceptScore W2000787023C28406088 @default.
- W2000787023 hasConceptScore W2000787023C50156730 @default.
- W2000787023 hasConceptScore W2000787023C55493867 @default.
- W2000787023 hasConceptScore W2000787023C71924100 @default.
- W2000787023 hasConceptScore W2000787023C79879829 @default.
- W2000787023 hasConceptScore W2000787023C86803240 @default.
- W2000787023 hasConceptScore W2000787023C98274493 @default.
- W2000787023 hasIssue "2" @default.
- W2000787023 hasLocation W20007870231 @default.
- W2000787023 hasLocation W20007870232 @default.
- W2000787023 hasOpenAccess W2000787023 @default.
- W2000787023 hasPrimaryLocation W20007870231 @default.
- W2000787023 hasRelatedWork W1992689150 @default.
- W2000787023 hasRelatedWork W1995953249 @default.
- W2000787023 hasRelatedWork W2000787023 @default.
- W2000787023 hasRelatedWork W2013273018 @default.
- W2000787023 hasRelatedWork W2022294881 @default.
- W2000787023 hasRelatedWork W2083576828 @default.
- W2000787023 hasRelatedWork W2110143838 @default.
- W2000787023 hasRelatedWork W2147282433 @default.
- W2000787023 hasRelatedWork W2393521223 @default.
- W2000787023 hasRelatedWork W2413658046 @default.
- W2000787023 hasVolume "458" @default.
- W2000787023 isParatext "false" @default.
- W2000787023 isRetracted "false" @default.
- W2000787023 magId "2000787023" @default.
- W2000787023 workType "article" @default.