FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000788236> ?p ?o ?g. }

• W2000788236 endingPage "88" @default.
• W2000788236 startingPage "88" @default.
• W2000788236 abstract "Objective: Defects in the genes that regulate developmental processes lead to a wide range of embryonic, fetal and neonatal defects, from minor cosmetic abnormalities, to disasters that terminate pregnancies within a few days to weeks after fertilization. We sought to determine if the presence of defects in placental villous development, specifically trophoblast inclusions (TIs: cross sections of deep invaginations of the villous trophoblast bilayer, Figure), is a marker of genetically abnormal pregnancies. Design: Multicenter retrospective slide review with comparisons made between normal deliveries, elective terminations and spontaneous abortions. Materials and Methods: Chorionic villi from 855 elective terminations (TABs), 303 spontaneous losses (SABs) and 820 normal term deliveries were examined microscopically for the presence of TIs (defined as at least one trophoblast inclusion identified microscopically in the available material). 138 of the SABs were karyotyped, of which 77 were excluded (all normal 46, XX cases and cases where no villi were present for microscopic review), leaving 61 for analysis. Results: Comparison of TABs to all SABs revealed that 24/855 TABs had TIs compared to 81/303 SABs with TIs (sens 27%, spec 97%, PPV 77%, NPV 79%). Comparison of these same TABs to karyotypically characterized SABs revealed that 32/48 karyotypically abnormal SABs had TIs (sens 67%, spec 97%, PPV 57%, NPV 98%). Comparison of normal term deliveries to karyotypically characterized SABs revealed that 21/820 term placentas had TIs compared to 32/48 karyotypically abnormal SABs with TIs (sens 67%, spec 97%, PPV 60%, NPV 98%). When only SABs were compared, 1/13 SABs with normal karyotypes had TIs compared to 32/48 karyotypically abnormal SABs with TIs (sens 67%, spec 92%, PPV 97%, NPV 43%). Conclusions: We have observed that trophoblast inclusions are commonly found in the placentas of fetuses with known chromosomal abnormalities, are more commonly found in SABs compared to TABs, and are rare in normal term placentas. Abnormalities that affect the regulation of such basic cell processes as proliferation, cell movement and fusion are likely reflected in abnormal placental growth patterns, which can give rise to trophoblast inclusions. Since the fetus and placenta share the same genome (except in rare cases of confined placental mosaicism), the presence of trophoblast inclusions may serve as a marker for fetal genetic abnormalities." @default.
• W2000788236 created "2016-06-24" @default.
• W2000788236 creator A5031097078 @default.
• W2000788236 creator A5043343360 @default.
• W2000788236 creator A5064323091 @default.
• W2000788236 creator A5067009816 @default.
• W2000788236 creator A5081636386 @default.
• W2000788236 creator A5090014755 @default.
• W2000788236 date "2003-09-01" @default.
• W2000788236 modified "2023-10-01" @default.
• W2000788236 title "Trophoblast inclusions are rare in elective terminations and normal deliveries, but common in cases with karyotypic abnormalities" @default.
• W2000788236 doi "https://doi.org/10.1016/s0015-0282(03)02035-1" @default.
• W2000788236 hasPublicationYear "2003" @default.
• W2000788236 type Work @default.
• W2000788236 sameAs 2000788236 @default.
• W2000788236 citedByCount "6" @default.
• W2000788236 countsByYear W20007882362013 @default.
• W2000788236 countsByYear W20007882362014 @default.
• W2000788236 countsByYear W20007882362017 @default.
• W2000788236 countsByYear W20007882362021 @default.
• W2000788236 countsByYear W20007882362022 @default.
• W2000788236 countsByYear W20007882362023 @default.
• W2000788236 crossrefType "journal-article" @default.
• W2000788236 hasAuthorship W2000788236A5031097078 @default.
• W2000788236 hasAuthorship W2000788236A5043343360 @default.
• W2000788236 hasAuthorship W2000788236A5064323091 @default.
• W2000788236 hasAuthorship W2000788236A5067009816 @default.
• W2000788236 hasAuthorship W2000788236A5081636386 @default.
• W2000788236 hasAuthorship W2000788236A5090014755 @default.
• W2000788236 hasBestOaLocation W20007882361 @default.
• W2000788236 hasConcept C104317684 @default.
• W2000788236 hasConcept C142724271 @default.
• W2000788236 hasConcept C16685009 @default.
• W2000788236 hasConcept C172680121 @default.
• W2000788236 hasConcept C2776953305 @default.
• W2000788236 hasConcept C2777495146 @default.
• W2000788236 hasConcept C2779234561 @default.
• W2000788236 hasConcept C2781385326 @default.
• W2000788236 hasConcept C30481170 @default.
• W2000788236 hasConcept C45167389 @default.
• W2000788236 hasConcept C53226629 @default.
• W2000788236 hasConcept C54355233 @default.
• W2000788236 hasConcept C71924100 @default.
• W2000788236 hasConcept C86803240 @default.
• W2000788236 hasConceptScore W2000788236C104317684 @default.
• W2000788236 hasConceptScore W2000788236C142724271 @default.
• W2000788236 hasConceptScore W2000788236C16685009 @default.
• W2000788236 hasConceptScore W2000788236C172680121 @default.
• W2000788236 hasConceptScore W2000788236C2776953305 @default.
• W2000788236 hasConceptScore W2000788236C2777495146 @default.
• W2000788236 hasConceptScore W2000788236C2779234561 @default.
• W2000788236 hasConceptScore W2000788236C2781385326 @default.
• W2000788236 hasConceptScore W2000788236C30481170 @default.
• W2000788236 hasConceptScore W2000788236C45167389 @default.
• W2000788236 hasConceptScore W2000788236C53226629 @default.
• W2000788236 hasConceptScore W2000788236C54355233 @default.
• W2000788236 hasConceptScore W2000788236C71924100 @default.
• W2000788236 hasConceptScore W2000788236C86803240 @default.
• W2000788236 hasLocation W20007882361 @default.
• W2000788236 hasOpenAccess W2000788236 @default.
• W2000788236 hasPrimaryLocation W20007882361 @default.
• W2000788236 hasRelatedWork W1968094849 @default.
• W2000788236 hasRelatedWork W2016919977 @default.
• W2000788236 hasRelatedWork W2027671904 @default.
• W2000788236 hasRelatedWork W2154968797 @default.
• W2000788236 hasRelatedWork W2222113668 @default.
• W2000788236 hasRelatedWork W2906633821 @default.
• W2000788236 hasRelatedWork W3081625826 @default.
• W2000788236 hasRelatedWork W3114476681 @default.
• W2000788236 hasRelatedWork W4212995182 @default.
• W2000788236 hasRelatedWork W4220655077 @default.
• W2000788236 hasVolume "80" @default.
• W2000788236 isParatext "false" @default.
• W2000788236 isRetracted "false" @default.
• W2000788236 magId "2000788236" @default.
• W2000788236 workType "article" @default.