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- W2000788248 abstract "Abstract We have shown that vitamin E inhibited the apoptosis, DNA modification and cancer induced by iron-mediated peroxidation in the Wistar rat kidney. To further elucidate the effects of vitamin E, we examined the levels of apoptosis and 8-hydroxydeoxyguanosine (8-OHdG) in vitamin E-deficient, -normal (control) and -supplemented rats after a single intraperitoneal injection of ferric nitrilotriacetate (Fe-NTA). Three-week-old male Wistar rats were divided into three groups and maintained on a vitamin E-deficient, -normal or -supplemented diet for 6 weeks. At the end of the 6-week feeding period, the animals were injected intraperitoneally with Fe-NTA or saline. The vitamin E-deficient rats injected with Fe-NTA 3 or 8 mg Fe per kg body weight died within 3.5 h, whereas the vitamin E-normal and -supplemented animals all survived ( n =6 each). In other rats maintained on the above vitamin E diets ( n =13 each), the levels of apoptosis shown by the TUNEL method and 8-OHdG formation shown by immunohistochemistry and an HPLC–ECD method were defined in renal tissues after an intraperitoneal injection of Fe-NTA, 8 mg Fe per kg body weight. The results showed that the generation of both 8-OHdG and apoptosis were definitely inhibited in the vitamin E-supplemented animals, whereas little inhibition was seen in the vitamin E-normal animals. However, the lack of vitamin E induced death by iron-induced oxidative stress with remarkable proximal tubular necrosis and hemolysis." @default.
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- W2000788248 date "1999-12-01" @default.
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- W2000788248 title "Apoptosis and 8-hydroxydeoxyguanosine levels in renal tissue after an injection of ferric nitrilotriacetate, a renal carcinogen, in male Wistar rats maintained on vitamin E-deficient, -normal or -supplemented diets" @default.
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- W2000788248 doi "https://doi.org/10.1016/s0928-4680(99)00006-1" @default.
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