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- W2000788377 abstract "The crystal structure of the nucleoside 2',3'-dideoxyformycin A has been determined. The structure shows a syn conformation about the glycosidic bond, stabilised by an intramolecular hydrogen bond between the 05' and N3 atoms. HIV activity was examined in a syncytium inhibition assay. In contrast to the marked decrease in viral titre observed with 2',3'-dideoxycytidine, the formycin analogue produced no effect. It may be concluded that the syn conformation for a dideoxy nucleoside is probably deleterious to HIV inhibition of HIV replication." @default.
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- W2000788377 date "1989-06-01" @default.
- W2000788377 modified "2023-09-23" @default.
- W2000788377 title "The anti-conformation of 2′,3′-dideoxy nucleosides may be essential for anti-HIV activity: Evidence from the crystal structure of 2′,3′-dideoxy formycin A" @default.
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- W2000788377 doi "https://doi.org/10.1016/0006-291x(89)92685-5" @default.
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