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• W2000788497 abstract "The experimental evidence for the facilitation of O2 diffusion in the presence of Hb or Mb was reviewed. The basic characteristics of facilitated O2 diffusion pointed out the diffusive nature of this process and excluded other mechanisms proposed (e.g., a “bucket-brigade” mechanism). A review of the earlier attempts at a quantitative treatment of facilitated O2 diffusion showed deficiencies concerning both the premises for the theoretical approach and the availability of adequate experimental data for the basic parameters. The situation with respect to the facilitated diffusion of CO in particular suggested the possible importance of the chemical reaction rates. It was also found that the problem of the simultaneous gradients of O2 and HbO2 in the diffusion layer remained unsolved. The more recent experimental data for the diffusion coefficients of O2, Hb and Mb were summarized as a basis for further quantitative treatment. The recent mathematical work by the author of the present review was briefly described and showed that a quantitative description of the experimental evidence was possible based on the facilitated O2 diffusion being interpreted as simultaneous diffusion of O2 and HbO2 if the chemical reaction rates were also taken into account. The possible physiological significance of facilitated O2 diffusion in vivo was discussed, including nonsteady-state conditions as present under most physiological circumstances, with particular reference to the situation concerning Hb in the red cells and concerning Mb in muscle. It was concluded that more circumstantial and direct experimental evidence is needed in order to arrive at a definite evaluation of the importance of facilitated O2 diffusion in physiological conditions." @default.
• W2000788497 created "2016-06-24" @default.
• W2000788497 creator A5061690588 @default.
• W2000788497 date "1970-04-01" @default.
• W2000788497 modified "2023-10-18" @default.
• W2000788497 title "Facilitated diffusion of oxygen and its possible significance; a review" @default.
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• W2000788497 doi "https://doi.org/10.1016/0034-5687(70)90002-2" @default.
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