FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000789260> ?p ?o ?g. }

• W2000789260 endingPage "1514" @default.
• W2000789260 startingPage "1505" @default.
• W2000789260 abstract "Abstract Calnuc, a Golgi calcium binding protein, plays a key role in the constitution of calcium storage. Abnormal calcium homeostasis has been linked to Alzheimer’s disease (AD). Excessive production and/or accumulation of β‐amyloid (Aβ) peptides that are proteolytically derived from the β‐amyloid precursor protein (APP) have been linked to the pathogenesis of AD. APP has also been indicated to play multiple physiological functions. In this study, we demonstrate that calnuc interacts with APP through direct binding to the carboxyl‐terminal region of APP, possibly in a calcium‐sensitive manner. Immunofluorescence study revealed that the two proteins co‐localize in the Golgi in both cultured cells and mouse brains. Over‐expression of calnuc in neuroblastoma cells significantly reduces the level of endogenous APP. Conversely, down‐regulation of calnuc by siRNA increases cellular levels of APP. Additionally, we show that over‐expression of calnuc down‐regulates the APP mRNA level and inhibits APP biosynthesis, which in turn results in a parallel reduction of APP proteolytic metabolites, sAPP, CTFs and Aβ. Furthermore, we found that the level of calnuc was significantly decreased in the brain of AD patients as compared with that of age‐matched non‐AD controls. Our results suggest a novel function of calnuc in modulating the levels of APP and its proteolytic metabolites, which may further affect the patho/physiological functions of APP including AD pathogenesis." @default.
• W2000789260 created "2016-06-24" @default.
• W2000789260 creator A5010227886 @default.
• W2000789260 creator A5037313550 @default.
• W2000789260 creator A5038389980 @default.
• W2000789260 creator A5043869758 @default.
• W2000789260 creator A5048121498 @default.
• W2000789260 creator A5074982084 @default.
• W2000789260 creator A5081844561 @default.
• W2000789260 date "2006-11-13" @default.
• W2000789260 modified "2023-10-16" @default.
• W2000789260 title "Calnuc binds to Alzheimer’s β‐amyloid precursor protein and affects its biogenesis" @default.
• W2000789260 cites W1577244262 @default.
• W2000789260 cites W1580327310 @default.
• W2000789260 cites W1585690852 @default.
• W2000789260 cites W1599485383 @default.
• W2000789260 cites W1762207349 @default.
• W2000789260 cites W181624336 @default.
• W2000789260 cites W1972061334 @default.
• W2000789260 cites W1975775468 @default.
• W2000789260 cites W1979240613 @default.
• W2000789260 cites W1979773315 @default.
• W2000789260 cites W1986810511 @default.
• W2000789260 cites W1988986946 @default.
• W2000789260 cites W1993050097 @default.
• W2000789260 cites W1997197588 @default.
• W2000789260 cites W1999203392 @default.
• W2000789260 cites W2006290814 @default.
• W2000789260 cites W2011258376 @default.
• W2000789260 cites W2015013133 @default.
• W2000789260 cites W2017205324 @default.
• W2000789260 cites W2018833058 @default.
• W2000789260 cites W2034255563 @default.
• W2000789260 cites W2046443709 @default.
• W2000789260 cites W2055697619 @default.
• W2000789260 cites W2068923731 @default.
• W2000789260 cites W2070107613 @default.
• W2000789260 cites W2074438246 @default.
• W2000789260 cites W2074562451 @default.
• W2000789260 cites W2075485544 @default.
• W2000789260 cites W2076199082 @default.
• W2000789260 cites W2080274663 @default.
• W2000789260 cites W2081598019 @default.
• W2000789260 cites W2086539466 @default.
• W2000789260 cites W2090639965 @default.
• W2000789260 cites W2092680193 @default.
• W2000789260 cites W2094375064 @default.
• W2000789260 cites W2096110602 @default.
• W2000789260 cites W2098068232 @default.
• W2000789260 cites W2105704879 @default.
• W2000789260 cites W2107198564 @default.
• W2000789260 cites W2110888808 @default.
• W2000789260 cites W2114504280 @default.
• W2000789260 cites W2131773654 @default.
• W2000789260 cites W2133561989 @default.
• W2000789260 cites W2143930939 @default.
• W2000789260 cites W2145395978 @default.
• W2000789260 cites W2149854899 @default.
• W2000789260 cites W2153609006 @default.
• W2000789260 cites W2155863144 @default.
• W2000789260 cites W2159762641 @default.
• W2000789260 cites W2169152986 @default.
• W2000789260 cites W2418785714 @default.
• W2000789260 doi "https://doi.org/10.1111/j.1471-4159.2006.04336.x" @default.
• W2000789260 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17348862" @default.
• W2000789260 hasPublicationYear "2006" @default.
• W2000789260 type Work @default.
• W2000789260 sameAs 2000789260 @default.
• W2000789260 citedByCount "16" @default.
• W2000789260 countsByYear W20007892602015 @default.
• W2000789260 countsByYear W20007892602016 @default.
• W2000789260 countsByYear W20007892602017 @default.
• W2000789260 countsByYear W20007892602019 @default.
• W2000789260 countsByYear W20007892602020 @default.
• W2000789260 countsByYear W20007892602022 @default.
• W2000789260 countsByYear W20007892602023 @default.
• W2000789260 crossrefType "journal-article" @default.
• W2000789260 hasAuthorship W2000789260A5010227886 @default.
• W2000789260 hasAuthorship W2000789260A5037313550 @default.
• W2000789260 hasAuthorship W2000789260A5038389980 @default.
• W2000789260 hasAuthorship W2000789260A5043869758 @default.
• W2000789260 hasAuthorship W2000789260A5048121498 @default.
• W2000789260 hasAuthorship W2000789260A5074982084 @default.
• W2000789260 hasAuthorship W2000789260A5081844561 @default.
• W2000789260 hasBestOaLocation W20007892601 @default.
• W2000789260 hasConcept C104317684 @default.
• W2000789260 hasConcept C119062480 @default.
• W2000789260 hasConcept C126322002 @default.
• W2000789260 hasConcept C131934819 @default.
• W2000789260 hasConcept C158617107 @default.
• W2000789260 hasConcept C175344181 @default.
• W2000789260 hasConcept C185592680 @default.
• W2000789260 hasConcept C203014093 @default.
• W2000789260 hasConcept C2777633098 @default.
• W2000789260 hasConcept C2779134260 @default.
• W2000789260 hasConcept C2780942790 @default.
• W2000789260 hasConcept C31705614 @default.
• W2000789260 hasConcept C36103677 @default.

• next