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- W2000790011 abstract "The six cortical layers have distinct anatomical and physiological properties, like different energy use and different feedforward and feedback connectivity. It is not known if and how layer-specific neural processes are reflected in the fMRI signal. To address this question we used high-resolution fMRI to measure BOLD, CBV, and CBF responses to stimuli that elicit positive and negative BOLD signals in macaque primary visual cortex. We found that regions with positive BOLD responses had parallel increases in CBV and CBF, whereas areas with negative BOLD responses showed a decrease in CBF but an increase in CBV. For positive BOLD responses, CBF and CBV increased in the center of the cortex, but for negative BOLD responses, CBF decreased superficially while CBV increased in the center. Our findings suggest different mechanisms for neurovascular coupling for BOLD increases and decreases, as well as laminar differences in neurovascular coupling." @default.
- W2000790011 created "2016-06-24" @default.
- W2000790011 creator A5003997696 @default.
- W2000790011 creator A5030092141 @default.
- W2000790011 creator A5038503198 @default.
- W2000790011 date "2012-11-01" @default.
- W2000790011 modified "2023-10-16" @default.
- W2000790011 title "High-Resolution fMRI Reveals Laminar Differences in Neurovascular Coupling between Positive and Negative BOLD Responses" @default.
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- W2000790011 doi "https://doi.org/10.1016/j.neuron.2012.09.019" @default.
- W2000790011 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5234326" @default.
- W2000790011 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23141073" @default.
- W2000790011 hasPublicationYear "2012" @default.
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