FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000793078> ?p ?o ?g. }

• W2000793078 endingPage "883" @default.
• W2000793078 startingPage "877" @default.
• W2000793078 abstract "Steroid hormone receptors are members of a family of ligand inducible transcription factors, and regulate the transcriptional activation of target genes by recruiting coregulatory proteins to the pre-initiation machinery. The binding of these coregulatory proteins to the steroid hormone receptors is often mediated through their two activation functional domains, AF1, which resides in the N-terminal domain, and the ligand-dependent AF2, which is localized in the C-terminal ligand-binding domain. Compared to other important functional domains of the steroid hormone receptors, our understanding of the mechanisms of action of the AF1 are incomplete, in part, due to the fact that, in solution, AF1 is intrinsically disordered (ID). However, recent studies have shown that AF1 must adopt a functionally active and folded conformation for its optimal activity under physiological conditions. In this review, we summarize and discuss current knowledge regarding the molecular mechanisms of AF1-mediated gene activation, focusing on AF1 conformation and coactivator binding. We further propose models for the binding/folding of the AF1 domains of the steroid hormone receptors and their protein:protein interactions. The population of ID AF1 can be visualized as a collection of many different conformations, some of which may be assuming the proper functional folding for other critical target binding partners that result in the ultimate assembly of AF1:coactivator complexes and subsequent gene regulation. Knowledge of the mechanisms involved therein will significantly help in understanding how signals from a steroid to a specific target gene are conveyed." @default.
• W2000793078 created "2016-06-24" @default.
• W2000793078 creator A5007780827 @default.
• W2000793078 creator A5062814155 @default.
• W2000793078 date "2009-11-01" @default.
• W2000793078 modified "2023-10-15" @default.
• W2000793078 title "Structural and functional relationships of the steroid hormone receptors’ N-terminal transactivation domain" @default.
• W2000793078 cites W1491569850 @default.
• W2000793078 cites W1495912963 @default.
• W2000793078 cites W15018734 @default.
• W2000793078 cites W1723187988 @default.
• W2000793078 cites W1907321242 @default.
• W2000793078 cites W1964247670 @default.
• W2000793078 cites W1965758787 @default.
• W2000793078 cites W1975121208 @default.
• W2000793078 cites W1975271726 @default.
• W2000793078 cites W1975329922 @default.
• W2000793078 cites W1977047025 @default.
• W2000793078 cites W1979136542 @default.
• W2000793078 cites W1979266919 @default.
• W2000793078 cites W1981306061 @default.
• W2000793078 cites W1981516673 @default.
• W2000793078 cites W1982607030 @default.
• W2000793078 cites W1984134696 @default.
• W2000793078 cites W1985921281 @default.
• W2000793078 cites W1986492725 @default.
• W2000793078 cites W1993294667 @default.
• W2000793078 cites W1996127793 @default.
• W2000793078 cites W2002662963 @default.
• W2000793078 cites W2006192061 @default.
• W2000793078 cites W2007016963 @default.
• W2000793078 cites W2007169317 @default.
• W2000793078 cites W2010764705 @default.
• W2000793078 cites W2011983814 @default.
• W2000793078 cites W2012324003 @default.
• W2000793078 cites W2015606278 @default.
• W2000793078 cites W2016709672 @default.
• W2000793078 cites W2021059897 @default.
• W2000793078 cites W2021632119 @default.
• W2000793078 cites W2025760262 @default.
• W2000793078 cites W2028605407 @default.
• W2000793078 cites W2034299708 @default.
• W2000793078 cites W2036441940 @default.
• W2000793078 cites W2044915892 @default.
• W2000793078 cites W2045077315 @default.
• W2000793078 cites W2045206677 @default.
• W2000793078 cites W2046121745 @default.
• W2000793078 cites W2046745425 @default.
• W2000793078 cites W2049734794 @default.
• W2000793078 cites W2052606462 @default.
• W2000793078 cites W2053535211 @default.
• W2000793078 cites W2060903877 @default.
• W2000793078 cites W2066928008 @default.
• W2000793078 cites W2071689903 @default.
• W2000793078 cites W2073390629 @default.
• W2000793078 cites W2073745520 @default.
• W2000793078 cites W2078537140 @default.
• W2000793078 cites W2079080809 @default.
• W2000793078 cites W2085124463 @default.
• W2000793078 cites W2092153867 @default.
• W2000793078 cites W2094558395 @default.
• W2000793078 cites W2094600324 @default.
• W2000793078 cites W2101738855 @default.
• W2000793078 cites W2102827103 @default.
• W2000793078 cites W2104360623 @default.
• W2000793078 cites W2105259330 @default.
• W2000793078 cites W2116474322 @default.
• W2000793078 cites W2119693327 @default.
• W2000793078 cites W2120040531 @default.
• W2000793078 cites W2128254124 @default.
• W2000793078 cites W2131144673 @default.
• W2000793078 cites W2132185105 @default.
• W2000793078 cites W2132554625 @default.
• W2000793078 cites W2133833261 @default.
• W2000793078 cites W2139031643 @default.
• W2000793078 cites W2147859244 @default.
• W2000793078 cites W2149865992 @default.
• W2000793078 cites W2150228320 @default.
• W2000793078 cites W2151888740 @default.
• W2000793078 cites W2151922331 @default.
• W2000793078 cites W2162720882 @default.
• W2000793078 cites W2164424178 @default.
• W2000793078 cites W2169457085 @default.
• W2000793078 cites W2319691036 @default.
• W2000793078 cites W4230288882 @default.
• W2000793078 cites W4241870034 @default.
• W2000793078 cites W4242699920 @default.
• W2000793078 cites W4248123998 @default.
• W2000793078 cites W4251788516 @default.
• W2000793078 cites W4254463777 @default.
• W2000793078 cites W4255596717 @default.
• W2000793078 doi "https://doi.org/10.1016/j.steroids.2009.07.012" @default.
• W2000793078 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3074935" @default.
• W2000793078 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19666041" @default.
• W2000793078 hasPublicationYear "2009" @default.
• W2000793078 type Work @default.
• W2000793078 sameAs 2000793078 @default.
• W2000793078 citedByCount "43" @default.

• next