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- W2000793812 endingPage "582" @default.
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- W2000793812 abstract "Recent advances in molecular techniques and high-resolution imaging are beginning to provide exciting insights into the higher order chromatin organization within the cell nucleus and its influence on eukaryotic gene regulation. This improved understanding of gene regulation also raises fundamental questions about how spatial features might have constrained the organization of genes on eukaryotic chromosomes and how mutations that affect these processes might contribute to disease conditions. In this review, we discuss recent studies that highlight the role of spatial components in gene regulation and their impact on genome evolution. We then address implications for human diseases and outline new directions for future research." @default.
- W2000793812 created "2016-06-24" @default.
- W2000793812 creator A5056494907 @default.
- W2000793812 creator A5066167699 @default.
- W2000793812 creator A5070136083 @default.
- W2000793812 creator A5075202721 @default.
- W2000793812 date "2008-12-01" @default.
- W2000793812 modified "2023-09-27" @default.
- W2000793812 title "Eukaryotic gene regulation in three dimensions and its impact on genome evolution" @default.
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