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- W2000795541 abstract "Rheumatoid factors (RFs) are the first autoantibodies described in rheumatoid arthritis (RA), which target the Fc region of IgG. Since their discovery, RFs have been the subject of extensive studies not just because of their association with RA, but also because they serve as an excellent model for the regulation and induction of disease-related autoantibodies. Although RFs are normally induced during secondary immune responses, isotype switching and affinity maturation are confined to RA patients and are not observed in normal individuals. Therefore, the emergence of high-affinity RFs, which are believed to depend on T-cell help, is under strict control in normal subjects, whereas these control mechanisms appear to be bypassed in RA. In this article, we provide an overview of the current knowledge of how pathologic RFs are induced and discuss the mechanisms by which RFs contribute to RA disease process." @default.
- W2000795541 created "2016-06-24" @default.
- W2000795541 creator A5054304061 @default.
- W2000795541 creator A5088973805 @default.
- W2000795541 date "2010-12-01" @default.
- W2000795541 modified "2023-09-28" @default.
- W2000795541 title "The pathogenic role of rheumatoid factor in rheumatoid arthritis" @default.
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- W2000795541 doi "https://doi.org/10.2217/ijr.10.62" @default.
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