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- W2000795717 abstract "Studies in this laboratory have shown that the application of local combined simultaneous heat and X-rays significantly increased local tumor control and cure in mice bearing an SV- 40 fibrosarcoma in the limb and in humans bearing metastatic or locally recurrent tumors. The present studies were carried out in order to investigate the relations involved in the radiosensitization of tumor tissues with different local heating temperatures and different doses of ionizing radiation. (BALB/C × C57BL/6)F1 mice, bearing an SV- 40 fibrosarcoma in the limb, were exposed to (a) local X-rays alone ( 500–800 rads); (b) local hyperthermia alone (hot air temperatures 45°C, 50°C, 55°C ); duration of heat treatment 15, 30 and 45 min), and (c) simultaneous heat and radiation in various combinations of (a) and (b). Hyperthermia was achieved by means of hot air. Heating and X-irradiation were administered separately or simultaneously once, or twice after a 7 -day interval. The results confirm our previous conclusions that although the SV- 40 tumor is both poorly thermosensitive and radioresistant, the synergistic effect of heat and irradiation is striking. The tumor response to the combined simultaneous treatment indicates that the radiation enhancement effect depends upon the local heating temperature and duration, and upon the X-ray dose. It is apparent from these data that the combined simultaneous treatment has a synergistic effect on neoplastic tissues and has important implications in radiation therapy of human cancer." @default.
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- W2000795717 date "1976-10-01" @default.
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- W2000795717 title "Treatment of a solid tumor by local simultaneous hyperthermia and ionizing radiation: Dependence on temperature and dose" @default.
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- W2000795717 doi "https://doi.org/10.1016/0014-2964(76)90095-5" @default.
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