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- W2000796435 abstract "The administration of IL-1, a potent radioprotective cytokine, before allogeneic BMT is associated with an early transient increase of circulating granulocytes, successful engraftment, and accelerated multilineage hematopoietic recovery. We have examined the effects of IL-1 alpha pretreatment on the engraftment of an allogeneic BMT unable to sustain survival by itself after a lethal irradiation: (1) transplantation of a limited amount of marrow cells and (2) transplantation several days after irradiation. IL-1 was unable to allow the engraftment of an early quantitatively inadequate BMT. However, delayed BMT with limited amounts of marrow cells was associated with engraftment in IL-1-pretreated recipients. Engraftment of a late (day 12) BMT in these IL-1-pretreated mice was comparable to the engraftment of a similar day 12 allogeneic BMT in non-IL-1-pretreated mice rescued from the lethal irradiation by an early (day 1) syngeneic graft. These findings demonstrate that IL-1 pretreatment can result in a dissociation between BMT-induced survival and engraftment and suggest that the favorable effects of IL-1 pretreatment in an allogeneic BMT setting are mainly mediated through a transient enhancement of endogenous hematopoiesis and not through a direct effect on the allogeneic stem cells present in the marrow graft." @default.
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- W2000796435 date "1996-02-01" @default.
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- W2000796435 title "EVIDENCE THAT A TRANSIENT ENHANCEMENT OF ENDOGENOUS HEMATOPOIESIS CONTRIBUTES SIGNIFICANTLY TO THE FAVORABLE OUTCOME FOLLOWING INTERLEUKIN 1 PRETREATMENT AND ALLOGENEIC BONE MARROW TRANSPLANTATION1" @default.
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- W2000796435 doi "https://doi.org/10.1097/00007890-199602270-00031" @default.
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