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- W2000797914 abstract "<h3>Objective:</h3> This study assessed the tissue integrity of major cervical cord tracts by using diffusion tensor imaging (DTI) to determine the relationship with specific clinical functions carried by those tracts. <h3>Methods:</h3> This was a cross-sectional study of 37 patients with multiple sclerosis or neuromyelitis optica with remote cervical cord disease. Finger vibratory thresholds, 25-foot timed walk (25FTW), 9-hole peg test (9HPT), and Expanded Disability Status Scale were determined. DTI covered cervical regions C1 through C6 with 17 5-mm slices (0.9 × 0.9 mm in-plane resolution). Regions of interest included posterior columns (PCs) and lateral corticospinal tracts (CSTs). Hierarchical linear mixed-effect modeling included covariates of disease subtype (multiple sclerosis vs neuromyelitis optica), disease duration, and sex. <h3>Results:</h3> Vibration thresholds were associated with radial diffusivity (RD) and fractional anisotropy (FA) in the PCs (both <i>p</i> < 0.01), but not CSTs (RD, <i>p</i> = 0.29; FA, <i>p</i> = 0.14). RD and FA in PCs, and RD in CSTs were related to 9HPT (each <i>p</i> < 0.0001). 25FTW was associated with RD and FA in PCs (<i>p</i> < 0.0001) and RD in CSTs (<i>p</i> = 0.008). Expanded Disability Status Scale was related to RD and FA in PCs and CSTs (<i>p</i> < 0.0001). Moderate/severe impairments in 9HPT (<i>p</i> = 0.006) and 25FTW (<i>p</i> = 0.017) were more likely to show combined moderate/severe tissue injury within both PCs and CSTs by DTI. <h3>Conclusions:</h3> DTI can serve as an imaging biomarker of spinal cord tissue injury at the tract level. RD and FA demonstrate strong and consistent relationships with clinical outcomes, specific to the clinical modality." @default.
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- W2000797914 date "2013-05-10" @default.
- W2000797914 modified "2023-09-23" @default.
- W2000797914 title "Spinal cord tract diffusion tensor imaging reveals disability substrate in demyelinating disease" @default.
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- W2000797914 doi "https://doi.org/10.1212/wnl.0b013e318296e8f1" @default.
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