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- W2000797940 abstract "The transforming Growth Factor β (TGFβ) signaling pathway is a prominent regulatory signaling pathway controlling various important cellular processes. TGFβ signaling can be induced by several factors including ionizing radiation. The pathway is regulated in a negative feedback loop through promoting the nuclear import of the regulatory Smads and a subsequent expression of inhibitory Smad7, that forms ubiquitin ligase with Smurf2, targeting active TGFβ receptors for degradation. In this work, we proposed a mathematical model to study the Smad-regulated TGFβ signaling pathway. By modularization, we are able to analyze mathematically each component subsystem and recover the nonlinear dynamics of the entire network system. Meanwhile the excitability, a common feature observed in the biological systems, in the TGFβ signaling pathway is discussed and supported as well by numerical simulation, indicating the robustness of the model." @default.
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- W2000797940 date "2012-12-01" @default.
- W2000797940 modified "2023-09-28" @default.
- W2000797940 title "Modularized Smad-regulated TGFβ signaling pathway" @default.
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- W2000797940 doi "https://doi.org/10.1016/j.mbs.2012.07.005" @default.
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