Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000797986> ?p ?o ?g. }
- W2000797986 endingPage "747" @default.
- W2000797986 startingPage "740" @default.
- W2000797986 abstract "Activation of innate immunity against viruses in the respiratory tracts affects the development of asthma. Most respiratory viruses generate double-stranded (ds)RNA during their replication. We recently showed that a low-dose administration of polyinosinic polycytidylic acid (poly IC), a mimetic of viral dsRNA, during allergen sensitization augments airway eosinophilia and hyperresponsiveness in mice via enhanced production of IL-13 from T cells. However, a phenotype of asthma under severer load of dsRNA remains unknown. d-galactosamine (d-GalN) is known as a strong sensitizer of poly IC. Mice were treated with poly IC plus d-GalN during allergen sensitization. A sublethal dose of poly IC/d-GalN augmented airway eosinophilia and CD4(+) T-cell accumulation in the lungs but not airway hyperresponsiveness. The augmented inflammation was associated with decreased IL-10 in the bronchoalveolar lavage fluid and decreased Foxp3(+) regulatory T cells in the lungs. Serum IL-6 was prominently higher in the mice treated with poly IC/d-GalN than in that with poly IC alone or d-GalN alone. Poly IC/d-GalN did not affect IL-17-producing T cells in the lungs. Poly IC/d-GalN failed to augment airway eosinophilia after anti-IL-10 receptor monoclonal antibody treatment during allergen challenge. Finally, anti-IL-6 receptor monoclonal antibody treatment before poly IC/d-GalN completely prevented the decrease of IL-10 and Foxp3(+) regulatory T cells and the augmentation of airway inflammation. These results indicate that enhanced production of IL-6 by poly IC/d-GalN induces the augmentation of allergic inflammation via suppression of Foxp3(+) regulatory T-cell/IL-10 axis. IL-6 may be a target for preventing asthma augmentation related to severe virus infection." @default.
- W2000797986 created "2016-06-24" @default.
- W2000797986 creator A5001419629 @default.
- W2000797986 creator A5002352529 @default.
- W2000797986 creator A5003016795 @default.
- W2000797986 creator A5036516013 @default.
- W2000797986 creator A5039145045 @default.
- W2000797986 creator A5046949265 @default.
- W2000797986 creator A5053425024 @default.
- W2000797986 creator A5065564013 @default.
- W2000797986 creator A5066482394 @default.
- W2000797986 creator A5068349057 @default.
- W2000797986 date "2012-06-01" @default.
- W2000797986 modified "2023-09-26" @default.
- W2000797986 title "IL-6 Induced by Double-Stranded RNA Augments Allergic Inflammation via Suppression of Foxp3<sup>+</sup> T-Cell/IL-10 Axis" @default.
- W2000797986 cites W1708330158 @default.
- W2000797986 cites W1967311384 @default.
- W2000797986 cites W1970657386 @default.
- W2000797986 cites W1974551699 @default.
- W2000797986 cites W1980673401 @default.
- W2000797986 cites W1980699161 @default.
- W2000797986 cites W1987303083 @default.
- W2000797986 cites W1998846885 @default.
- W2000797986 cites W1999502885 @default.
- W2000797986 cites W2008926994 @default.
- W2000797986 cites W2013601771 @default.
- W2000797986 cites W2016297238 @default.
- W2000797986 cites W2018828712 @default.
- W2000797986 cites W2023761225 @default.
- W2000797986 cites W2028575270 @default.
- W2000797986 cites W2032435813 @default.
- W2000797986 cites W2036966708 @default.
- W2000797986 cites W2039423387 @default.
- W2000797986 cites W2046064200 @default.
- W2000797986 cites W2047882259 @default.
- W2000797986 cites W2050181420 @default.
- W2000797986 cites W2061006944 @default.
- W2000797986 cites W2067492674 @default.
- W2000797986 cites W2076361525 @default.
- W2000797986 cites W2078201105 @default.
- W2000797986 cites W2081691697 @default.
- W2000797986 cites W2092289140 @default.
- W2000797986 cites W2093579074 @default.
- W2000797986 cites W2097575786 @default.
- W2000797986 cites W2107513655 @default.
- W2000797986 cites W2130421043 @default.
- W2000797986 cites W2137303998 @default.
- W2000797986 cites W2137379305 @default.
- W2000797986 cites W2137843680 @default.
- W2000797986 cites W2141137217 @default.
- W2000797986 cites W2142967107 @default.
- W2000797986 cites W2144768687 @default.
- W2000797986 cites W2155779547 @default.
- W2000797986 cites W2156441288 @default.
- W2000797986 cites W2156472038 @default.
- W2000797986 cites W2157954415 @default.
- W2000797986 cites W2185210951 @default.
- W2000797986 cites W4246291556 @default.
- W2000797986 doi "https://doi.org/10.1165/rcmb.2010-0479oc" @default.
- W2000797986 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21799119" @default.
- W2000797986 hasPublicationYear "2012" @default.
- W2000797986 type Work @default.
- W2000797986 sameAs 2000797986 @default.
- W2000797986 citedByCount "8" @default.
- W2000797986 countsByYear W20007979862013 @default.
- W2000797986 countsByYear W20007979862014 @default.
- W2000797986 countsByYear W20007979862015 @default.
- W2000797986 countsByYear W20007979862017 @default.
- W2000797986 countsByYear W20007979862021 @default.
- W2000797986 countsByYear W20007979862022 @default.
- W2000797986 crossrefType "journal-article" @default.
- W2000797986 hasAuthorship W2000797986A5001419629 @default.
- W2000797986 hasAuthorship W2000797986A5002352529 @default.
- W2000797986 hasAuthorship W2000797986A5003016795 @default.
- W2000797986 hasAuthorship W2000797986A5036516013 @default.
- W2000797986 hasAuthorship W2000797986A5039145045 @default.
- W2000797986 hasAuthorship W2000797986A5046949265 @default.
- W2000797986 hasAuthorship W2000797986A5053425024 @default.
- W2000797986 hasAuthorship W2000797986A5065564013 @default.
- W2000797986 hasAuthorship W2000797986A5066482394 @default.
- W2000797986 hasAuthorship W2000797986A5068349057 @default.
- W2000797986 hasConcept C126322002 @default.
- W2000797986 hasConcept C141105273 @default.
- W2000797986 hasConcept C153911025 @default.
- W2000797986 hasConcept C159654299 @default.
- W2000797986 hasConcept C185592680 @default.
- W2000797986 hasConcept C203014093 @default.
- W2000797986 hasConcept C2776217527 @default.
- W2000797986 hasConcept C2776914184 @default.
- W2000797986 hasConcept C2777129736 @default.
- W2000797986 hasConcept C2777714996 @default.
- W2000797986 hasConcept C2777961210 @default.
- W2000797986 hasConcept C2779727006 @default.
- W2000797986 hasConcept C71924100 @default.
- W2000797986 hasConcept C86803240 @default.
- W2000797986 hasConcept C8891405 @default.
- W2000797986 hasConceptScore W2000797986C126322002 @default.
- W2000797986 hasConceptScore W2000797986C141105273 @default.