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• W2000798119 endingPage "317" @default.
• W2000798119 startingPage "303" @default.
• W2000798119 abstract "Poly(ADP-ribose) polymerase-1 (PARP-1) is the guardian of the genome acting as a sentinel for genomic damage. However, PARP-1 is also mediator of cell death after ischemia-reperfusion injury, glutamate excitotoxicity, and various inflammatory processes. The biochemistry underlying PARP-1-mediated cell death has remained elusive, although NAD(+) consumption and energy failure have been thought to be one of the possible molecular mechanisms. Recent observations link PARP-1 activation with translocation of apoptosis-inducing factor (AIF) to the nucleus and indicate that AIF is an essential downstream effector of PARP-1-mediated cell death. PARP-1 activation signals AIF release from the mitochondria, resulting in a novel, caspase-independent pathway of programmed cell death. These recent findings suggest that AIF maybe a target for development of future therapeutic treatment for many neurological disorders involving excitotoxicity." @default.
• W2000798119 created "2016-06-24" @default.
• W2000798119 creator A5009007964 @default.
• W2000798119 creator A5021759485 @default.
• W2000798119 creator A5025568267 @default.
• W2000798119 creator A5056786640 @default.
• W2000798119 date "2003-12-01" @default.
• W2000798119 modified "2023-10-12" @default.
• W2000798119 title "Poly(ADP-ribose) polymerase-1 and apoptosis inducing factor in neurotoxicity" @default.
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