Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000798536> ?p ?o ?g. }
- W2000798536 endingPage "1802" @default.
- W2000798536 startingPage "1784" @default.
- W2000798536 abstract "Cancer remains a major killer of mankind. Failure of conventional chemotherapy has resulted in recurrence and development of virulent multi drug resistant (MDR) phenotypes adding to the complexity and diversity of this deadly disease. Apart from displaying classical physiological abnormalities and aberrant blood flow behavior, MDR cancers exhibit several distinctive features such as higher apoptotic threshold, aerobic glycolysis, regions of hypoxia, and elevated activity of drug-efflux transporters. MDR transporters play a pivotal role in protecting the cancer stem cells (CSCs) from chemotherapy. It is speculated that CSCs are instrumental in reviving tumors after the chemo and radiotherapy. In this regard, multifunctional nanoparticles that can integrate various key components such as drugs, genes, imaging agents and targeting ligands using unique delivery platforms would be more efficient in treating MDR cancers. This review presents some of the important principles involved in development of MDR and novel methods of treating cancers using multifunctional-targeted nanoparticles. Illustrative examples of nanoparticles engineered for drug/gene combination delivery and stimuli responsive nanoparticle systems for cancer therapy are also discussed." @default.
- W2000798536 created "2016-06-24" @default.
- W2000798536 creator A5045993993 @default.
- W2000798536 creator A5064469636 @default.
- W2000798536 creator A5067909461 @default.
- W2000798536 creator A5089773835 @default.
- W2000798536 date "2013-11-01" @default.
- W2000798536 modified "2023-10-17" @default.
- W2000798536 title "Role of integrated cancer nanomedicine in overcoming drug resistance" @default.
- W2000798536 cites W1493048246 @default.
- W2000798536 cites W153338696 @default.
- W2000798536 cites W1534849470 @default.
- W2000798536 cites W1964146045 @default.
- W2000798536 cites W1964674353 @default.
- W2000798536 cites W1965278057 @default.
- W2000798536 cites W1965349053 @default.
- W2000798536 cites W1965805426 @default.
- W2000798536 cites W1966235893 @default.
- W2000798536 cites W1967196235 @default.
- W2000798536 cites W1967489230 @default.
- W2000798536 cites W1969332290 @default.
- W2000798536 cites W1969929756 @default.
- W2000798536 cites W1972441060 @default.
- W2000798536 cites W1973345865 @default.
- W2000798536 cites W1973701873 @default.
- W2000798536 cites W1975912702 @default.
- W2000798536 cites W1976066035 @default.
- W2000798536 cites W1976807210 @default.
- W2000798536 cites W1977755432 @default.
- W2000798536 cites W1978584972 @default.
- W2000798536 cites W1978635875 @default.
- W2000798536 cites W1982299508 @default.
- W2000798536 cites W1982321597 @default.
- W2000798536 cites W1989064705 @default.
- W2000798536 cites W1989264803 @default.
- W2000798536 cites W1990444855 @default.
- W2000798536 cites W1991782658 @default.
- W2000798536 cites W1992215904 @default.
- W2000798536 cites W1992519958 @default.
- W2000798536 cites W1992572371 @default.
- W2000798536 cites W1992676863 @default.
- W2000798536 cites W1993666713 @default.
- W2000798536 cites W1993683005 @default.
- W2000798536 cites W1993927293 @default.
- W2000798536 cites W1994003621 @default.
- W2000798536 cites W1994259790 @default.
- W2000798536 cites W1994567670 @default.
- W2000798536 cites W1995323554 @default.
- W2000798536 cites W1998571779 @default.
- W2000798536 cites W1999327728 @default.
- W2000798536 cites W1999356404 @default.
- W2000798536 cites W1999494701 @default.
- W2000798536 cites W1999672487 @default.
- W2000798536 cites W2001891615 @default.
- W2000798536 cites W2002516695 @default.
- W2000798536 cites W2003770685 @default.
- W2000798536 cites W2004656384 @default.
- W2000798536 cites W2005299431 @default.
- W2000798536 cites W2005769964 @default.
- W2000798536 cites W2006076866 @default.
- W2000798536 cites W2006434892 @default.
- W2000798536 cites W2007558231 @default.
- W2000798536 cites W2008171455 @default.
- W2000798536 cites W2009886857 @default.
- W2000798536 cites W2011090397 @default.
- W2000798536 cites W2012495753 @default.
- W2000798536 cites W2012867962 @default.
- W2000798536 cites W2013270956 @default.
- W2000798536 cites W2013470095 @default.
- W2000798536 cites W2013875806 @default.
- W2000798536 cites W2014124238 @default.
- W2000798536 cites W2014871497 @default.
- W2000798536 cites W2015606598 @default.
- W2000798536 cites W2015626183 @default.
- W2000798536 cites W2015831734 @default.
- W2000798536 cites W2016579192 @default.
- W2000798536 cites W2016747572 @default.
- W2000798536 cites W2018693859 @default.
- W2000798536 cites W2018729653 @default.
- W2000798536 cites W2019264784 @default.
- W2000798536 cites W2019633596 @default.
- W2000798536 cites W2019917635 @default.
- W2000798536 cites W2020552396 @default.
- W2000798536 cites W2021385919 @default.
- W2000798536 cites W2022832994 @default.
- W2000798536 cites W2023427658 @default.
- W2000798536 cites W2023876494 @default.
- W2000798536 cites W2024641423 @default.
- W2000798536 cites W2025919388 @default.
- W2000798536 cites W2026379260 @default.
- W2000798536 cites W2027000660 @default.
- W2000798536 cites W2027137358 @default.
- W2000798536 cites W2028350610 @default.
- W2000798536 cites W2028593825 @default.
- W2000798536 cites W2029231546 @default.
- W2000798536 cites W2030452459 @default.
- W2000798536 cites W2030498396 @default.
- W2000798536 cites W2030537876 @default.