FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000798782> ?p ?o ?g. }

• W2000798782 endingPage "69" @default.
• W2000798782 startingPage "63" @default.
• W2000798782 abstract "To analyze HER2 amplification in a large cohort of diagnostic breast cancer specimens, fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC) were performed on the same specimens with use of Food and Drug Administration—approved products. Procedures were standardized following the manufacturers' recommendations. Of 116,736 IHC specimens, 20% were positive for HER2. In 16,092 FISH specimens, 22.7% showed HER2 amplification. In the subset of 6556 tissues analyzed with IHC and FISH, however, 59% were positive on IHC and 23.6% were amplified on FISH. The increased frequency of positive test results is skewed by more frequent reflex FISH testing. In general, expression and amplification trended together, with the least amplification (4.1%) seen in IHC-negative cases, 7.4% amplification seen in IHC 1+ cases, 23.3% amplification seen in IHC 2+ cases, and 91.7% amplification seen in IHC 3+ cases. When FISH amplification ratios were stratified, the low FISH ratios (2.0-2.2) were most frequently seen in specimens with negative IHC results, high ratios (> 5.0) were seen in IHC 3+ specimens, and intermediate levels of amplification were similar for all levels of IHC. The effect of changing the cutoff point was analyzed: removing cases with a ratio of exactly 2.0 decreased the FISH positivity rate to 22.2% in the combined IHC and FISH cohort. Sequentially moving the cutoff point to 2.2 and 2.5 affected cases at all IHC expression levels. Each change removed approximately 2% from the apparent positivity. This large database provides the distribution frequency of HER2 protein expression and gene amplification in invasive ductal and lobular breast cancer. The relationship between level of HER2 amplification and clinical outcome will require reanalysis of pivotal trial data." @default.
• W2000798782 created "2016-06-24" @default.
• W2000798782 creator A5004964452 @default.
• W2000798782 creator A5007518983 @default.
• W2000798782 creator A5032655063 @default.
• W2000798782 date "2004-04-01" @default.
• W2000798782 modified "2023-09-25" @default.
• W2000798782 title "HER2 Amplification Ratios by Fluorescence In Situ Hybridization and Correlation with Immunohistochemistry in a Cohort of 6556 Breast Cancer Tissues" @default.
• W2000798782 cites W1772131958 @default.
• W2000798782 cites W1867197625 @default.
• W2000798782 cites W1904016327 @default.
• W2000798782 cites W1924784781 @default.
• W2000798782 cites W1925485320 @default.
• W2000798782 cites W1972090515 @default.
• W2000798782 cites W1986314326 @default.
• W2000798782 cites W1990761134 @default.
• W2000798782 cites W1991847152 @default.
• W2000798782 cites W1999329028 @default.
• W2000798782 cites W2014909020 @default.
• W2000798782 cites W2015172444 @default.
• W2000798782 cites W2022895967 @default.
• W2000798782 cites W2046946053 @default.
• W2000798782 cites W2061563172 @default.
• W2000798782 cites W2076440683 @default.
• W2000798782 cites W2092491717 @default.
• W2000798782 cites W2095156669 @default.
• W2000798782 cites W2100716241 @default.
• W2000798782 cites W2104528117 @default.
• W2000798782 cites W2104872563 @default.
• W2000798782 cites W2107413762 @default.
• W2000798782 cites W2110442763 @default.
• W2000798782 cites W2125730396 @default.
• W2000798782 cites W2139713460 @default.
• W2000798782 cites W2141393790 @default.
• W2000798782 cites W2154027407 @default.
• W2000798782 cites W2156544288 @default.
• W2000798782 cites W2159459001 @default.
• W2000798782 cites W2164789874 @default.
• W2000798782 cites W2167167632 @default.
• W2000798782 cites W2170832900 @default.
• W2000798782 cites W4249993376 @default.
• W2000798782 cites W4253149507 @default.
• W2000798782 doi "https://doi.org/10.3816/cbc.2004.n.011" @default.
• W2000798782 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15140287" @default.
• W2000798782 hasPublicationYear "2004" @default.
• W2000798782 type Work @default.
• W2000798782 sameAs 2000798782 @default.
• W2000798782 citedByCount "584" @default.
• W2000798782 countsByYear W20007987822012 @default.
• W2000798782 countsByYear W20007987822013 @default.
• W2000798782 countsByYear W20007987822014 @default.
• W2000798782 countsByYear W20007987822015 @default.
• W2000798782 countsByYear W20007987822016 @default.
• W2000798782 countsByYear W20007987822017 @default.
• W2000798782 countsByYear W20007987822018 @default.
• W2000798782 countsByYear W20007987822019 @default.
• W2000798782 countsByYear W20007987822020 @default.
• W2000798782 countsByYear W20007987822021 @default.
• W2000798782 countsByYear W20007987822022 @default.
• W2000798782 countsByYear W20007987822023 @default.
• W2000798782 crossrefType "journal-article" @default.
• W2000798782 hasAuthorship W2000798782A5004964452 @default.
• W2000798782 hasAuthorship W2000798782A5007518983 @default.
• W2000798782 hasAuthorship W2000798782A5032655063 @default.
• W2000798782 hasConcept C104317684 @default.
• W2000798782 hasConcept C121608353 @default.
• W2000798782 hasConcept C126322002 @default.
• W2000798782 hasConcept C142724271 @default.
• W2000798782 hasConcept C150194340 @default.
• W2000798782 hasConcept C204232928 @default.
• W2000798782 hasConcept C2777542201 @default.
• W2000798782 hasConcept C2909208804 @default.
• W2000798782 hasConcept C30481170 @default.
• W2000798782 hasConcept C505870484 @default.
• W2000798782 hasConcept C530470458 @default.
• W2000798782 hasConcept C54355233 @default.
• W2000798782 hasConcept C71924100 @default.
• W2000798782 hasConcept C81439078 @default.
• W2000798782 hasConcept C86803240 @default.
• W2000798782 hasConceptScore W2000798782C104317684 @default.
• W2000798782 hasConceptScore W2000798782C121608353 @default.
• W2000798782 hasConceptScore W2000798782C126322002 @default.
• W2000798782 hasConceptScore W2000798782C142724271 @default.
• W2000798782 hasConceptScore W2000798782C150194340 @default.
• W2000798782 hasConceptScore W2000798782C204232928 @default.
• W2000798782 hasConceptScore W2000798782C2777542201 @default.
• W2000798782 hasConceptScore W2000798782C2909208804 @default.
• W2000798782 hasConceptScore W2000798782C30481170 @default.
• W2000798782 hasConceptScore W2000798782C505870484 @default.
• W2000798782 hasConceptScore W2000798782C530470458 @default.
• W2000798782 hasConceptScore W2000798782C54355233 @default.
• W2000798782 hasConceptScore W2000798782C71924100 @default.
• W2000798782 hasConceptScore W2000798782C81439078 @default.
• W2000798782 hasConceptScore W2000798782C86803240 @default.
• W2000798782 hasIssue "1" @default.
• W2000798782 hasLocation W20007987821 @default.
• W2000798782 hasLocation W20007987822 @default.
• W2000798782 hasOpenAccess W2000798782 @default.

• next