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- W2000799894 abstract "Plasma cells daily secrete their own mass in antibodies, which fold and assemble in the endoplasmic reticulum (ER). To reach these levels, cells require pERp1, a novel lymphocyte-specific small ER-resident protein, which attains expression levels as high as BiP when B cells differentiate into plasma cells. Although pERp1 has no homology with known ER proteins, it does contain a CXXC motif typical for oxidoreductases. In steady state, the CXXC cysteines are locked by two parallel disulfide bonds with a downstream C(X) 6 C motif, and pERp1 displays only modest oxidoreductase activity. pERp1 emerged as a dedicated folding factor for IgM, associating with both heavy and light chains and promoting assembly and secretion of mature IgM." @default.
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- W2000799894 date "2009-10-06" @default.
- W2000799894 modified "2023-10-16" @default.
- W2000799894 title "Efficient IgM assembly and secretion require the plasma cell induced endoplasmic reticulum protein pERp1" @default.
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- W2000799894 doi "https://doi.org/10.1073/pnas.0903036106" @default.
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