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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000801600> ?p ?o ?g. }

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• W2000801600 abstract "La fonction des IAP (inhibitors of apoptosis proteins) a longtemps été restreinte à une inhibition de l’apoptose, en raison de leur capacité à lier directement certaines caspases. La mise en évidence d’altérations de l’expression de ces protéines dans des échantillons tumoraux en a fait des cibles privilégiées pour les traitements anticancéreux. De nombreuses molécules ont été développées dans le but d’inhiber la capacité de liaison des IAP avec les caspases. De façon inattendue, ces molécules altèrent considérablement la signalisation NF-κB. Dans cette revue, nous discuterons des travaux récents montrant un rôle central de cIAP1, cIAP2 et XIAP dans la régulation des voies de signalisation conduisant à une activation de NF-κB." @default.
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• W2000801600 date "2012-01-01" @default.
• W2000801600 modified "2023-10-03" @default.
• W2000801600 title "Les IAP au cœur de la signalisation NF-κB" @default.
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• W2000801600 doi "https://doi.org/10.1051/medsci/2012281019" @default.
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