FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000802108> ?p ?o ?g. }

• W2000802108 endingPage "e61102" @default.
• W2000802108 startingPage "e61102" @default.
• W2000802108 abstract "Background Effectiveness of ART regimens strongly depends upon complex interactions between the selective pressure of drugs and the evolution of mutations that allow or restrict drug resistance. Methods Four clinical isolates from NRTI-exposed, NNRTI-naive subjects were passaged in increasing concentrations of NVP in combination with 1 µM 3 TC and 2 µM ADV to assess selective pressures of multi-drug treatment. A novel parameter inference procedure, based on a stochastic viral growth model, was used to estimate phenotypic resistance and fitness from in vitro combination passage experiments. Results Newly developed mathematical methods estimated key phenotypic parameters of mutations arising through selective pressure exerted by 3 TC and NVP. Concentrations of 1 µM 3 TC maintained the M184V mutation, which was associated with intrinsic fitness deficits. Increasing NVP concentrations selected major NNRTI resistance mutations. The evolutionary pathway of NVP resistance was highly dependent on the viral genetic background, epistasis as well as stochasticity. Parameter estimation indicated that the previously unrecognized mutation L228Q was associated with NVP resistance in some isolates. Conclusion Serial passage of viruses in the presence of multiple drugs may resemble the selection of mutations observed among treated individuals and populations in vivo and indicate evolutionary preferences and restrictions. Phenotypic resistance estimated here “in silico” from in vitro passage experiments agreed well with previous knowledge, suggesting that the unique combination of “wet-” and “dry-lab” experimentation may improve our understanding of HIV-1 resistance evolution in the future." @default.
• W2000802108 created "2016-06-24" @default.
• W2000802108 creator A5024344697 @default.
• W2000802108 creator A5042232387 @default.
• W2000802108 creator A5052739345 @default.
• W2000802108 creator A5057954330 @default.
• W2000802108 creator A5066628402 @default.
• W2000802108 creator A5088027458 @default.
• W2000802108 creator A5089767325 @default.
• W2000802108 date "2013-04-17" @default.
• W2000802108 modified "2023-09-30" @default.
• W2000802108 title "In Vitro HIV-1 Evolution in Response to Triple Reverse Transcriptase Inhibitors & In Silico Phenotypic Analysis" @default.
• W2000802108 cites W1546727052 @default.
• W2000802108 cites W1985731319 @default.
• W2000802108 cites W1985827516 @default.
• W2000802108 cites W1986814711 @default.
• W2000802108 cites W1986852302 @default.
• W2000802108 cites W1991578028 @default.
• W2000802108 cites W1992949458 @default.
• W2000802108 cites W1995278079 @default.
• W2000802108 cites W2007636686 @default.
• W2000802108 cites W2009424749 @default.
• W2000802108 cites W2014842368 @default.
• W2000802108 cites W2015203095 @default.
• W2000802108 cites W2016185554 @default.
• W2000802108 cites W2025994885 @default.
• W2000802108 cites W2030034431 @default.
• W2000802108 cites W2033687798 @default.
• W2000802108 cites W2044403736 @default.
• W2000802108 cites W2051205639 @default.
• W2000802108 cites W2052381091 @default.
• W2000802108 cites W2055542167 @default.
• W2000802108 cites W2056271343 @default.
• W2000802108 cites W2056686421 @default.
• W2000802108 cites W2057111695 @default.
• W2000802108 cites W2065173886 @default.
• W2000802108 cites W2069388608 @default.
• W2000802108 cites W2071149185 @default.
• W2000802108 cites W2071747231 @default.
• W2000802108 cites W2073157159 @default.
• W2000802108 cites W2076322352 @default.
• W2000802108 cites W2078826836 @default.
• W2000802108 cites W2081089010 @default.
• W2000802108 cites W2082536602 @default.
• W2000802108 cites W2084273391 @default.
• W2000802108 cites W2084702672 @default.
• W2000802108 cites W2087508194 @default.
• W2000802108 cites W2088237531 @default.
• W2000802108 cites W2102821123 @default.
• W2000802108 cites W2105028368 @default.
• W2000802108 cites W2109046728 @default.
• W2000802108 cites W2131686757 @default.
• W2000802108 cites W2133104019 @default.
• W2000802108 cites W2138042650 @default.
• W2000802108 cites W2145277102 @default.
• W2000802108 cites W2148291080 @default.
• W2000802108 cites W2155599348 @default.
• W2000802108 cites W2156127238 @default.
• W2000802108 cites W2158013170 @default.
• W2000802108 cites W2159623444 @default.
• W2000802108 cites W2162521939 @default.
• W2000802108 cites W2319133153 @default.
• W2000802108 cites W4234011924 @default.
• W2000802108 cites W4297914773 @default.
• W2000802108 doi "https://doi.org/10.1371/journal.pone.0061102" @default.
• W2000802108 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3629221" @default.
• W2000802108 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23613794" @default.
• W2000802108 hasPublicationYear "2013" @default.
• W2000802108 type Work @default.
• W2000802108 sameAs 2000802108 @default.
• W2000802108 citedByCount "6" @default.
• W2000802108 countsByYear W20008021082014 @default.
• W2000802108 countsByYear W20008021082015 @default.
• W2000802108 countsByYear W20008021082016 @default.
• W2000802108 countsByYear W20008021082017 @default.
• W2000802108 countsByYear W20008021082019 @default.
• W2000802108 crossrefType "journal-article" @default.
• W2000802108 hasAuthorship W2000802108A5024344697 @default.
• W2000802108 hasAuthorship W2000802108A5042232387 @default.
• W2000802108 hasAuthorship W2000802108A5052739345 @default.
• W2000802108 hasAuthorship W2000802108A5057954330 @default.
• W2000802108 hasAuthorship W2000802108A5066628402 @default.
• W2000802108 hasAuthorship W2000802108A5088027458 @default.
• W2000802108 hasAuthorship W2000802108A5089767325 @default.
• W2000802108 hasBestOaLocation W20008021081 @default.
• W2000802108 hasConcept C104317684 @default.
• W2000802108 hasConcept C114851261 @default.
• W2000802108 hasConcept C127716648 @default.
• W2000802108 hasConcept C132351222 @default.
• W2000802108 hasConcept C156719811 @default.
• W2000802108 hasConcept C159047783 @default.
• W2000802108 hasConcept C182707283 @default.
• W2000802108 hasConcept C202751555 @default.
• W2000802108 hasConcept C2775905019 @default.
• W2000802108 hasConcept C501734568 @default.
• W2000802108 hasConcept C54355233 @default.
• W2000802108 hasConcept C61727976 @default.
• W2000802108 hasConcept C67705224 @default.

• next