FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000802362> ?p ?o ?g. }

• W2000802362 abstract "Chronic dermatitis, such as contact dermatitis (CD) or atopic dermatitis (AD), is a longstanding inflammatory skin disease with cutaneous damage such as erosion, ulceration, and lichenification due to itch-induced scratching. The resultant lesion can be considered to be a kind of wound. The tissue inhibitor metalloproteases-2 (TIMP-2) accelerates wound healing by enhancing the proliferation and migration of epidermal keratinocytes and dermal fibroblasts; it is also a physiologic inhibitor of matrix metalloproteinases. The aim of this study was to test the effect of TIMP-2 on chronic dermatitis. NC/Kuj mice were sensitized with Dermatophagoides farinae (Df) extract. Eczema was induced by repeated applications of this mite allergen to the skin of 20 sensitized mice that were maintained under specific pathogen-free conditions. One group of 10 mice was then treated with topical TIMP-2 solution (0.1 ml, 0.5%) for 28 days, and the other with vehicle alone and the effects of TIMP-2 were evaluated macro- and microscopically. The effect on skin barrier function was estimated by measuring transepidermal water loss (TEWL). Scoring of gross skin findings showed that TIMP-2 significantly reduced the severity of eczema (P<0.05) on days 12-28. Histological examination revealed that TIMP-2 treated mice manifested lower degrees of hyperkeratosis, acanthosis, and spongiosis in the epidermis and fewer inflammatory cells in the dermis than vehicle-treated mice. There were significant reductions in the epidermal thickness and dermal inflammatory cells in the TIMP-2 treated animals (P<0.01); their TEWL was significantly decreased on day 28 (P<0.05). Our results suggest that NC/Kuj mice with Df extract-induced chronic eczema may be a useful model for investigating chronic dermatitis, and that TIMP-2 may be a good agent for treating chronic dermatitis as well as chronic ulcers." @default.
• W2000802362 created "2016-06-24" @default.
• W2000802362 creator A5033200547 @default.
• W2000802362 creator A5073121970 @default.
• W2000802362 creator A5080220929 @default.
• W2000802362 creator A5087685739 @default.
• W2000802362 date "2005-05-01" @default.
• W2000802362 modified "2023-09-24" @default.
• W2000802362 title "Beneficial Effects of Tissue Inhibitor of Metalloproteinases-2 (TIMP-2) on Chronic Dermatitis" @default.
• W2000802362 cites W1970140945 @default.
• W2000802362 cites W1973070576 @default.
• W2000802362 cites W1980480613 @default.
• W2000802362 cites W1996935665 @default.
• W2000802362 cites W2002353349 @default.
• W2000802362 cites W2008795839 @default.
• W2000802362 cites W2010631109 @default.
• W2000802362 cites W2012909222 @default.
• W2000802362 cites W2013524931 @default.
• W2000802362 cites W2016391707 @default.
• W2000802362 cites W2041689797 @default.
• W2000802362 cites W2056105344 @default.
• W2000802362 cites W2067017343 @default.
• W2000802362 cites W2069399018 @default.
• W2000802362 cites W2070412924 @default.
• W2000802362 cites W2072755205 @default.
• W2000802362 cites W2075593866 @default.
• W2000802362 cites W2083147421 @default.
• W2000802362 cites W2092834073 @default.
• W2000802362 cites W2109658199 @default.
• W2000802362 cites W2127855281 @default.
• W2000802362 cites W2137722996 @default.
• W2000802362 doi "https://doi.org/10.1111/j.1346-8138.2005.tb00905.x" @default.
• W2000802362 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16043896" @default.
• W2000802362 hasPublicationYear "2005" @default.
• W2000802362 type Work @default.
• W2000802362 sameAs 2000802362 @default.
• W2000802362 citedByCount "8" @default.
• W2000802362 countsByYear W20008023622012 @default.
• W2000802362 countsByYear W20008023622013 @default.
• W2000802362 countsByYear W20008023622018 @default.
• W2000802362 countsByYear W20008023622021 @default.
• W2000802362 countsByYear W20008023622022 @default.
• W2000802362 crossrefType "journal-article" @default.
• W2000802362 hasAuthorship W2000802362A5033200547 @default.
• W2000802362 hasAuthorship W2000802362A5073121970 @default.
• W2000802362 hasAuthorship W2000802362A5080220929 @default.
• W2000802362 hasAuthorship W2000802362A5087685739 @default.
• W2000802362 hasConcept C105702510 @default.
• W2000802362 hasConcept C109523444 @default.
• W2000802362 hasConcept C121332964 @default.
• W2000802362 hasConcept C126322002 @default.
• W2000802362 hasConcept C142724271 @default.
• W2000802362 hasConcept C16005928 @default.
• W2000802362 hasConcept C203014093 @default.
• W2000802362 hasConcept C24890656 @default.
• W2000802362 hasConcept C2776458125 @default.
• W2000802362 hasConcept C2776914184 @default.
• W2000802362 hasConcept C2777624698 @default.
• W2000802362 hasConcept C2778329239 @default.
• W2000802362 hasConcept C2778370115 @default.
• W2000802362 hasConcept C2778478263 @default.
• W2000802362 hasConcept C2779915019 @default.
• W2000802362 hasConcept C2780182102 @default.
• W2000802362 hasConcept C2780196728 @default.
• W2000802362 hasConcept C2781156865 @default.
• W2000802362 hasConcept C51911345 @default.
• W2000802362 hasConcept C71924100 @default.
• W2000802362 hasConcept C86803240 @default.
• W2000802362 hasConcept C95150158 @default.
• W2000802362 hasConcept C95444343 @default.
• W2000802362 hasConceptScore W2000802362C105702510 @default.
• W2000802362 hasConceptScore W2000802362C109523444 @default.
• W2000802362 hasConceptScore W2000802362C121332964 @default.
• W2000802362 hasConceptScore W2000802362C126322002 @default.
• W2000802362 hasConceptScore W2000802362C142724271 @default.
• W2000802362 hasConceptScore W2000802362C16005928 @default.
• W2000802362 hasConceptScore W2000802362C203014093 @default.
• W2000802362 hasConceptScore W2000802362C24890656 @default.
• W2000802362 hasConceptScore W2000802362C2776458125 @default.
• W2000802362 hasConceptScore W2000802362C2776914184 @default.
• W2000802362 hasConceptScore W2000802362C2777624698 @default.
• W2000802362 hasConceptScore W2000802362C2778329239 @default.
• W2000802362 hasConceptScore W2000802362C2778370115 @default.
• W2000802362 hasConceptScore W2000802362C2778478263 @default.
• W2000802362 hasConceptScore W2000802362C2779915019 @default.
• W2000802362 hasConceptScore W2000802362C2780182102 @default.
• W2000802362 hasConceptScore W2000802362C2780196728 @default.
• W2000802362 hasConceptScore W2000802362C2781156865 @default.
• W2000802362 hasConceptScore W2000802362C51911345 @default.
• W2000802362 hasConceptScore W2000802362C71924100 @default.
• W2000802362 hasConceptScore W2000802362C86803240 @default.
• W2000802362 hasConceptScore W2000802362C95150158 @default.
• W2000802362 hasConceptScore W2000802362C95444343 @default.
• W2000802362 hasLocation W20008023621 @default.
• W2000802362 hasLocation W20008023622 @default.
• W2000802362 hasOpenAccess W2000802362 @default.
• W2000802362 hasPrimaryLocation W20008023621 @default.
• W2000802362 hasRelatedWork W1975012380 @default.
• W2000802362 hasRelatedWork W1989973775 @default.
• W2000802362 hasRelatedWork W2000802362 @default.

• next