Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000802375> ?p ?o ?g. }
- W2000802375 endingPage "5506" @default.
- W2000802375 startingPage "5493" @default.
- W2000802375 abstract "Abstract One of the earliest events in epithelial carcinogenesis is the dissolution of tight junctions and cell polarity signals that are essential for normal epithelial barrier function. Here, we report that EFA6B, a guanine nucleotide exchange factor for the Ras superfamily protein Arf6 that helps assemble and stabilize tight junction, is required to maintain apico-basal cell polarity and mesenchymal phenotypes in mammary epithelial cells. In organotypic three-dimensional cell cultures, endogenous levels of EFA6B were critical to determine epithelial–mesenchymal status. EFA6B downregulation correlated with a mesenchymal phenotype and ectopic expression of EFA6B hampered TGFβ-induced epithelial-to-mesenchymal transition (EMT). Transcriptomic and immunohistochemical analyses of human breast tumors revealed that the reduced expression of EFA6B was associated with loss of tight junction components and with increased signatures of EMT, cancer stemness, and poor prognosis. Accordingly, tumors with low levels of EFA6B were enriched in the aggressive triple-negative and claudin-low breast cancer subtypes. Our results identify EFA6B as a novel antagonist in breast cancer and they point to its regulatory and signaling pathways as rational therapeutic targets in aggressive forms of this disease. Cancer Res; 74(19); 5493–506. ©2014 AACR." @default.
- W2000802375 created "2016-06-24" @default.
- W2000802375 creator A5018374875 @default.
- W2000802375 creator A5020467193 @default.
- W2000802375 creator A5026016984 @default.
- W2000802375 creator A5029463040 @default.
- W2000802375 creator A5031085615 @default.
- W2000802375 creator A5033716671 @default.
- W2000802375 creator A5035891803 @default.
- W2000802375 creator A5051980875 @default.
- W2000802375 creator A5064649152 @default.
- W2000802375 creator A5064887458 @default.
- W2000802375 creator A5072157551 @default.
- W2000802375 creator A5073100067 @default.
- W2000802375 creator A5076674222 @default.
- W2000802375 creator A5084660376 @default.
- W2000802375 creator A5089171072 @default.
- W2000802375 creator A5091721810 @default.
- W2000802375 date "2014-09-30" @default.
- W2000802375 modified "2023-10-18" @default.
- W2000802375 title "EFA6B Antagonizes Breast Cancer" @default.
- W2000802375 cites W1532982575 @default.
- W2000802375 cites W1605218581 @default.
- W2000802375 cites W1760215417 @default.
- W2000802375 cites W1946623472 @default.
- W2000802375 cites W1967293289 @default.
- W2000802375 cites W1968358861 @default.
- W2000802375 cites W1994683536 @default.
- W2000802375 cites W1999132074 @default.
- W2000802375 cites W2002984398 @default.
- W2000802375 cites W2009410973 @default.
- W2000802375 cites W2021649658 @default.
- W2000802375 cites W2025690227 @default.
- W2000802375 cites W2028919524 @default.
- W2000802375 cites W2032461554 @default.
- W2000802375 cites W2042965279 @default.
- W2000802375 cites W2051672403 @default.
- W2000802375 cites W2054922344 @default.
- W2000802375 cites W2066950135 @default.
- W2000802375 cites W2082239705 @default.
- W2000802375 cites W2082643930 @default.
- W2000802375 cites W2093646219 @default.
- W2000802375 cites W2094535521 @default.
- W2000802375 cites W2099540110 @default.
- W2000802375 cites W2100269253 @default.
- W2000802375 cites W2106292881 @default.
- W2000802375 cites W2109319525 @default.
- W2000802375 cites W2110935705 @default.
- W2000802375 cites W2126464129 @default.
- W2000802375 cites W2126979211 @default.
- W2000802375 cites W2131994307 @default.
- W2000802375 cites W2135548733 @default.
- W2000802375 cites W2140159972 @default.
- W2000802375 cites W2140551998 @default.
- W2000802375 cites W2146414563 @default.
- W2000802375 cites W2146933781 @default.
- W2000802375 cites W2149441684 @default.
- W2000802375 cites W2153454576 @default.
- W2000802375 cites W2159526033 @default.
- W2000802375 cites W2166311434 @default.
- W2000802375 cites W4229894550 @default.
- W2000802375 doi "https://doi.org/10.1158/0008-5472.can-14-0298" @default.
- W2000802375 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25115298" @default.
- W2000802375 hasPublicationYear "2014" @default.
- W2000802375 type Work @default.
- W2000802375 sameAs 2000802375 @default.
- W2000802375 citedByCount "21" @default.
- W2000802375 countsByYear W20008023752015 @default.
- W2000802375 countsByYear W20008023752016 @default.
- W2000802375 countsByYear W20008023752017 @default.
- W2000802375 countsByYear W20008023752018 @default.
- W2000802375 countsByYear W20008023752019 @default.
- W2000802375 countsByYear W20008023752020 @default.
- W2000802375 countsByYear W20008023752021 @default.
- W2000802375 countsByYear W20008023752022 @default.
- W2000802375 crossrefType "journal-article" @default.
- W2000802375 hasAuthorship W2000802375A5018374875 @default.
- W2000802375 hasAuthorship W2000802375A5020467193 @default.
- W2000802375 hasAuthorship W2000802375A5026016984 @default.
- W2000802375 hasAuthorship W2000802375A5029463040 @default.
- W2000802375 hasAuthorship W2000802375A5031085615 @default.
- W2000802375 hasAuthorship W2000802375A5033716671 @default.
- W2000802375 hasAuthorship W2000802375A5035891803 @default.
- W2000802375 hasAuthorship W2000802375A5051980875 @default.
- W2000802375 hasAuthorship W2000802375A5064649152 @default.
- W2000802375 hasAuthorship W2000802375A5064887458 @default.
- W2000802375 hasAuthorship W2000802375A5072157551 @default.
- W2000802375 hasAuthorship W2000802375A5073100067 @default.
- W2000802375 hasAuthorship W2000802375A5076674222 @default.
- W2000802375 hasAuthorship W2000802375A5084660376 @default.
- W2000802375 hasAuthorship W2000802375A5089171072 @default.
- W2000802375 hasAuthorship W2000802375A5091721810 @default.
- W2000802375 hasBestOaLocation W20008023751 @default.
- W2000802375 hasConcept C104317684 @default.
- W2000802375 hasConcept C121608353 @default.
- W2000802375 hasConcept C126619667 @default.
- W2000802375 hasConcept C127561419 @default.
- W2000802375 hasConcept C177779419 @default.