Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000805010> ?p ?o ?g. }
- W2000805010 endingPage "159" @default.
- W2000805010 startingPage "147" @default.
- W2000805010 abstract "Type 2 diabetes mellitus (T2DM) is a complex disease characterized by insulin resistance and a progressive decline in β-cell function and mass. Current evidence suggests that β-cell dysfunction is present early in the course of the disease and that this dysfunction, rather than insulin resistance, is primarily responsible for the progression of T2DM. β-cell dysfunction can be accelerated by glucose toxicity, lipotoxicity, oxidative stress, chronic increases in inflammatory mediators and, potentially, the use of sulfonylureas. This review suggests that future efforts to limit the impact of T2DM must focus on strategies to preserve β-cell function. Several interventions have shown promise in this regard, including lifestyle modifications, thiazolidinediones, potassium channel openers, incretin mimetics, cytokine antagonists, bariatric surgery and dipeptidyl peptidase IV inhibitors, although therapeutic insulin remains the most robust and physiological approach." @default.
- W2000805010 created "2016-06-24" @default.
- W2000805010 creator A5091360325 @default.
- W2000805010 date "2008-03-01" @default.
- W2000805010 modified "2023-10-16" @default.
- W2000805010 title "Preserving insulin secretion in Type 2 diabetes mellitus" @default.
- W2000805010 cites W11872906 @default.
- W2000805010 cites W1561463821 @default.
- W2000805010 cites W1565673342 @default.
- W2000805010 cites W1964921050 @default.
- W2000805010 cites W1967005515 @default.
- W2000805010 cites W1974644955 @default.
- W2000805010 cites W1978766448 @default.
- W2000805010 cites W1980268126 @default.
- W2000805010 cites W1982293047 @default.
- W2000805010 cites W1983099475 @default.
- W2000805010 cites W1983908318 @default.
- W2000805010 cites W1988031087 @default.
- W2000805010 cites W1991737556 @default.
- W2000805010 cites W1996318348 @default.
- W2000805010 cites W1997459346 @default.
- W2000805010 cites W2000511325 @default.
- W2000805010 cites W2002362232 @default.
- W2000805010 cites W2004917045 @default.
- W2000805010 cites W2009766091 @default.
- W2000805010 cites W2011499650 @default.
- W2000805010 cites W2013389100 @default.
- W2000805010 cites W2014317180 @default.
- W2000805010 cites W2014887370 @default.
- W2000805010 cites W2020468088 @default.
- W2000805010 cites W2020599247 @default.
- W2000805010 cites W2021374152 @default.
- W2000805010 cites W2024378513 @default.
- W2000805010 cites W2024874163 @default.
- W2000805010 cites W2024992738 @default.
- W2000805010 cites W2026348270 @default.
- W2000805010 cites W2028038659 @default.
- W2000805010 cites W2029870728 @default.
- W2000805010 cites W2030153054 @default.
- W2000805010 cites W2031484324 @default.
- W2000805010 cites W2032422942 @default.
- W2000805010 cites W2035208902 @default.
- W2000805010 cites W2037447341 @default.
- W2000805010 cites W2037694172 @default.
- W2000805010 cites W2039085833 @default.
- W2000805010 cites W2039296612 @default.
- W2000805010 cites W2043121816 @default.
- W2000805010 cites W2043438273 @default.
- W2000805010 cites W2044437167 @default.
- W2000805010 cites W2048359273 @default.
- W2000805010 cites W2050826565 @default.
- W2000805010 cites W2056726092 @default.
- W2000805010 cites W2058009015 @default.
- W2000805010 cites W2060097209 @default.
- W2000805010 cites W2062219277 @default.
- W2000805010 cites W2064508323 @default.
- W2000805010 cites W2067184340 @default.
- W2000805010 cites W2067407687 @default.
- W2000805010 cites W2068488844 @default.
- W2000805010 cites W2077149049 @default.
- W2000805010 cites W2078830150 @default.
- W2000805010 cites W2081102637 @default.
- W2000805010 cites W2081276121 @default.
- W2000805010 cites W2082777764 @default.
- W2000805010 cites W2084644316 @default.
- W2000805010 cites W2085390992 @default.
- W2000805010 cites W2085862152 @default.
- W2000805010 cites W2086082646 @default.
- W2000805010 cites W2087061260 @default.
- W2000805010 cites W2090582239 @default.
- W2000805010 cites W2093545531 @default.
- W2000805010 cites W2094008351 @default.
- W2000805010 cites W2094434238 @default.
- W2000805010 cites W2097784879 @default.
- W2000805010 cites W2099378532 @default.
- W2000805010 cites W2100968639 @default.
- W2000805010 cites W2102400698 @default.
- W2000805010 cites W2107076497 @default.
- W2000805010 cites W2107851421 @default.
- W2000805010 cites W2112185825 @default.
- W2000805010 cites W2112535191 @default.
- W2000805010 cites W2114392594 @default.
- W2000805010 cites W2115177689 @default.
- W2000805010 cites W2118889627 @default.
- W2000805010 cites W2123415049 @default.
- W2000805010 cites W2124620553 @default.
- W2000805010 cites W2124924763 @default.
- W2000805010 cites W2126295203 @default.
- W2000805010 cites W2132806782 @default.
- W2000805010 cites W2133222023 @default.
- W2000805010 cites W2142140377 @default.
- W2000805010 cites W2145777702 @default.
- W2000805010 cites W2149502431 @default.
- W2000805010 cites W2153449155 @default.
- W2000805010 cites W2158822657 @default.
- W2000805010 cites W2159859567 @default.
- W2000805010 cites W2160234571 @default.
- W2000805010 cites W2160565799 @default.