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- W2000806179 abstract "This talk will discuss some aspects of the large scale regulatory network that controls the genetic expression of an E. coli cell as a whole. The expression of E. coli's 4-5 thousand genes is controlled by 150-200 transcription factors (TFs) and a few sigma factors. The activity of a TF or sigma factor is itself governed partly by external conditions such as temperature, pH and the chemical composition of the extracellular environment, and partly by the internal environment. The latter includes other TFs and sigma factors controlling the expression of the gene coding for the TF in question, molecules involved in post-transcriptional regulation, as well as metabolites that bind to the TF resulting in its regulation. The architecture of the global transcriptional regulatory network will be discussed, including feedbacks. A simple mathematical model that attempts to capture the dynamics of the switching on and off of the genes will be presented. This “global view” is “coarse grained”; it glosses over several details. However, this perspective reveals that the network as a whole has a rather special or particular character, which could be the basis of the cell's robustness and adaptability." @default.
- W2000806179 created "2016-06-24" @default.
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- W2000806179 date "2011-02-01" @default.
- W2000806179 modified "2023-09-30" @default.
- W2000806179 title "The Large Scale Genetic Regulatory Network of E. coli: Understanding Functional Robustness at the System Level" @default.
- W2000806179 doi "https://doi.org/10.1016/j.bpj.2010.12.2072" @default.
- W2000806179 hasPublicationYear "2011" @default.
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