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- W2000806957 endingPage "750" @default.
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- W2000806957 abstract "The original three-step batchwise synthesis of the pharmaceutical intermediate (1R,2S,4S)-(7-oxa-bicyclo[2.2.1]hept-2-yl)-carbamic acid ethyl ester (4) from (1R,2S,4S)-7-oxabicyclo[2.2.1]heptane-2-carboxylic acid ethyl ester (1) encompassed a highly exothermic hydrazine quenching step as well as an acylazide intermediate. After appropriately modifying the reaction conditions, all three steps could be adapted to a microreactor system and a continuous process which permitted the desired carbamate 4 to be prepared under safe operating conditions in yields of 96%, 94%, and 84% for the three individual steps." @default.
- W2000806957 created "2016-06-24" @default.
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- W2000806957 date "2009-05-20" @default.
- W2000806957 modified "2023-10-15" @default.
- W2000806957 title "Adaptation of an Exothermic and Acylazide-Involving Synthesis Sequence to Microreactor Technology" @default.
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- W2000806957 doi "https://doi.org/10.1021/op9000516" @default.
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