FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000807301> ?p ?o ?g. }

• W2000807301 endingPage "S49" @default.
• W2000807301 startingPage "S49" @default.
• W2000807301 abstract "Goals: Metaplastic carcinoma is distinct albeit, rare and aggressive formof invasive breast cancer. Histologically, these tumors exemplify enrichment of tumor initiating markers such as CD44 and ALDH1 along with low expression of CD24. Our aim was to review clinico-pathological and outcome data of patients diagnosed with metaplastic carcinoma at Aga Khan University and to correlate immunohiostochemical expression of CD44, CD24 and ALDH1 with overall survival. Methods: Cases were identified through breast cancer registry from 2000–2013. Immunohistochemical staining for CD44, CD24 and ALDH1 was performed on 5um serial sections of archival tumor blocks. Data was analyzed on SPSS 19 and overall survival was estimated by Kaplan–Meier. Results:Metaplastic carcinoma was diagnosed in 25 female patients with mean age of 54.6 years. Eighty-eight percent (22/25) cases had grade III tumors. ER and PR expression was observed in 52% and 36% cases, respectively. HER-2/neu overexpression and amplification was identified in 4% (1/25) and 13.3% (2/15) patients, respectively. Stage I disease was found in 4% (1/25) patients, 52% (13/25) had stage II, 36% (9/25) had stage III and 8% (2/25) patients had stage IV disease. Mean duration of follow-up was 23 months. Systemic recurrence developed in 24% (6/25) patients. Overall death rate was 28% (7/25). Membranous expression of CD44 was seen in 94% tumors whereas cytoplasmic expression of CD24 and ALDH1 was observed in 63% and 26.3% tumors, respectively. Six cases revealed CD44/ALDH1−/CD24− expression. Twopatients in this subgroup expired due to systemic metastasis, whereas the remaining 4 patients remained event free. ALDH/CD44/CD24 pattern of expression was observed in 4 patients and 1 patient in this subgroup expired due to systemic progression of stage IV disease. No significant difference was identified in median survival between CD44/CD24−, ALDH1−/CD24 and CD44/ALDH groups. Conclusion: In this study, prevalence of metaplastic carcinoma was 1.17%. Majority of patients presented with stage II disease and hormone receptor positivity. CD44 expression was detected in all except one tumor. ALDH1−/CD24 subgroup was associated with lower median overall survival however this was not statistically significant. Disclosure of Interest: No significant relationships." @default.
• W2000807301 created "2016-06-24" @default.
• W2000807301 creator A5005047688 @default.
• W2000807301 creator A5016433469 @default.
• W2000807301 creator A5034360760 @default.
• W2000807301 creator A5064678389 @default.
• W2000807301 creator A5065455821 @default.
• W2000807301 creator A5087789652 @default.
• W2000807301 date "2015-03-01" @default.
• W2000807301 modified "2023-10-18" @default.
• W2000807301 title "P064 Expression of tumor initiating markers in metaplastic carcinoma of the breast" @default.
• W2000807301 doi "https://doi.org/10.1016/s0960-9776(15)70114-1" @default.
• W2000807301 hasPublicationYear "2015" @default.
• W2000807301 type Work @default.
• W2000807301 sameAs 2000807301 @default.
• W2000807301 citedByCount "0" @default.
• W2000807301 crossrefType "journal-article" @default.
• W2000807301 hasAuthorship W2000807301A5005047688 @default.
• W2000807301 hasAuthorship W2000807301A5016433469 @default.
• W2000807301 hasAuthorship W2000807301A5034360760 @default.
• W2000807301 hasAuthorship W2000807301A5064678389 @default.
• W2000807301 hasAuthorship W2000807301A5065455821 @default.
• W2000807301 hasAuthorship W2000807301A5087789652 @default.
• W2000807301 hasBestOaLocation W20008073011 @default.
• W2000807301 hasConcept C121608353 @default.
• W2000807301 hasConcept C126322002 @default.
• W2000807301 hasConcept C142724271 @default.
• W2000807301 hasConcept C143998085 @default.
• W2000807301 hasConcept C2776047466 @default.
• W2000807301 hasConcept C502942594 @default.
• W2000807301 hasConcept C530470458 @default.
• W2000807301 hasConcept C71924100 @default.
• W2000807301 hasConceptScore W2000807301C121608353 @default.
• W2000807301 hasConceptScore W2000807301C126322002 @default.
• W2000807301 hasConceptScore W2000807301C142724271 @default.
• W2000807301 hasConceptScore W2000807301C143998085 @default.
• W2000807301 hasConceptScore W2000807301C2776047466 @default.
• W2000807301 hasConceptScore W2000807301C502942594 @default.
• W2000807301 hasConceptScore W2000807301C530470458 @default.
• W2000807301 hasConceptScore W2000807301C71924100 @default.
• W2000807301 hasLocation W20008073011 @default.
• W2000807301 hasOpenAccess W2000807301 @default.
• W2000807301 hasPrimaryLocation W20008073011 @default.
• W2000807301 hasRelatedWork W2003790128 @default.
• W2000807301 hasRelatedWork W2030676975 @default.
• W2000807301 hasRelatedWork W2041139504 @default.
• W2000807301 hasRelatedWork W2059021257 @default.
• W2000807301 hasRelatedWork W2098336367 @default.
• W2000807301 hasRelatedWork W2393987366 @default.
• W2000807301 hasRelatedWork W2406759654 @default.
• W2000807301 hasRelatedWork W2411117890 @default.
• W2000807301 hasRelatedWork W79559973 @default.
• W2000807301 hasRelatedWork W1989744586 @default.
• W2000807301 hasVolume "24" @default.
• W2000807301 isParatext "false" @default.
• W2000807301 isRetracted "false" @default.
• W2000807301 magId "2000807301" @default.
• W2000807301 workType "article" @default.