Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000808207> ?p ?o ?g. }
- W2000808207 endingPage "675" @default.
- W2000808207 startingPage "671" @default.
- W2000808207 abstract "The purpose of this study was to determine whether association of vasoactive intestinal peptide with sterically stabilized liposomes (VIP on SSL) amplifies DNA synthesis evoked by the peptide in cultured chemically transformed hamster oral keratinocytes (HCPC-1) and, if so, whether this response in mediated, in part, by SSL-induced inactivation of neutral endopeptidase 24.11 (NEP; EC 3.4.24.11) and angiotensin I-converting enzyme (ACE; EC 3.4.15.1), two ectoenzymes that modulate HCPC-1 cell growth, in these cells. We found that VIP (10(-9)-10(-6) M) alone elicited a modest, albeit significant, concentration-dependent increase in DNA synthesis in HCPC-1 cells that was maximal after 48-72-h incubation (p < 0.05). VIP on SSL potentiated DNA synthesis in these cells relative to VIP alone. The magnitude of VIP on SSL-induced responses was 1.2-1.6-fold higher than that of VIP alone with maximal effects observed at 10(-9) M and 10(-6) M after 72- and 48-h incubation, respectively. Empty SSL had no significant effects on DNA synthesis. Empty SSL and VIP on SSL had no significant effects on NEP 24.11 and ACE activity in HCPC-1 cells. Collectively, these data indicate that association of VIP with SSL potentiates DNA synthesis in cultured oral keratinocytes relative to VIP alone and that this response is not related to non-specific effects of SSL." @default.
- W2000808207 created "2016-06-24" @default.
- W2000808207 creator A5004947609 @default.
- W2000808207 creator A5028700223 @default.
- W2000808207 creator A5046482711 @default.
- W2000808207 creator A5049014528 @default.
- W2000808207 creator A5083877771 @default.
- W2000808207 date "2001-04-01" @default.
- W2000808207 modified "2023-10-06" @default.
- W2000808207 title "Liposomal VIP potentiates DNA synthesis in cultured oral keratinocytes" @default.
- W2000808207 cites W1936102867 @default.
- W2000808207 cites W1963540744 @default.
- W2000808207 cites W1964064464 @default.
- W2000808207 cites W1969040012 @default.
- W2000808207 cites W1978922111 @default.
- W2000808207 cites W1986788704 @default.
- W2000808207 cites W1987357649 @default.
- W2000808207 cites W1987645466 @default.
- W2000808207 cites W1994152572 @default.
- W2000808207 cites W1997464973 @default.
- W2000808207 cites W1997520373 @default.
- W2000808207 cites W2007123442 @default.
- W2000808207 cites W2008839265 @default.
- W2000808207 cites W2015241978 @default.
- W2000808207 cites W2018106895 @default.
- W2000808207 cites W2022152855 @default.
- W2000808207 cites W2023555336 @default.
- W2000808207 cites W2027716853 @default.
- W2000808207 cites W2043334596 @default.
- W2000808207 cites W2046964248 @default.
- W2000808207 cites W2051565317 @default.
- W2000808207 cites W2053904713 @default.
- W2000808207 cites W2060069140 @default.
- W2000808207 cites W2064516819 @default.
- W2000808207 cites W2066544551 @default.
- W2000808207 cites W2070307409 @default.
- W2000808207 cites W2121177571 @default.
- W2000808207 cites W2143671219 @default.
- W2000808207 cites W2162973484 @default.
- W2000808207 cites W2317805687 @default.
- W2000808207 cites W4293247451 @default.
- W2000808207 doi "https://doi.org/10.1016/s0196-9781(01)00377-1" @default.
- W2000808207 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11311738" @default.
- W2000808207 hasPublicationYear "2001" @default.
- W2000808207 type Work @default.
- W2000808207 sameAs 2000808207 @default.
- W2000808207 citedByCount "9" @default.
- W2000808207 countsByYear W20008082072021 @default.
- W2000808207 crossrefType "journal-article" @default.
- W2000808207 hasAuthorship W2000808207A5004947609 @default.
- W2000808207 hasAuthorship W2000808207A5028700223 @default.
- W2000808207 hasAuthorship W2000808207A5046482711 @default.
- W2000808207 hasAuthorship W2000808207A5049014528 @default.
- W2000808207 hasAuthorship W2000808207A5083877771 @default.
- W2000808207 hasConcept C118303440 @default.
- W2000808207 hasConcept C126322002 @default.
- W2000808207 hasConcept C134018914 @default.
- W2000808207 hasConcept C153911025 @default.
- W2000808207 hasConcept C170493617 @default.
- W2000808207 hasConcept C185592680 @default.
- W2000808207 hasConcept C25642318 @default.
- W2000808207 hasConcept C2779281246 @default.
- W2000808207 hasConcept C552990157 @default.
- W2000808207 hasConcept C55493867 @default.
- W2000808207 hasConcept C64241487 @default.
- W2000808207 hasConcept C71924100 @default.
- W2000808207 hasConcept C8330315 @default.
- W2000808207 hasConcept C86803240 @default.
- W2000808207 hasConceptScore W2000808207C118303440 @default.
- W2000808207 hasConceptScore W2000808207C126322002 @default.
- W2000808207 hasConceptScore W2000808207C134018914 @default.
- W2000808207 hasConceptScore W2000808207C153911025 @default.
- W2000808207 hasConceptScore W2000808207C170493617 @default.
- W2000808207 hasConceptScore W2000808207C185592680 @default.
- W2000808207 hasConceptScore W2000808207C25642318 @default.
- W2000808207 hasConceptScore W2000808207C2779281246 @default.
- W2000808207 hasConceptScore W2000808207C552990157 @default.
- W2000808207 hasConceptScore W2000808207C55493867 @default.
- W2000808207 hasConceptScore W2000808207C64241487 @default.
- W2000808207 hasConceptScore W2000808207C71924100 @default.
- W2000808207 hasConceptScore W2000808207C8330315 @default.
- W2000808207 hasConceptScore W2000808207C86803240 @default.
- W2000808207 hasIssue "4" @default.
- W2000808207 hasLocation W20008082071 @default.
- W2000808207 hasLocation W20008082072 @default.
- W2000808207 hasOpenAccess W2000808207 @default.
- W2000808207 hasPrimaryLocation W20008082071 @default.
- W2000808207 hasRelatedWork W1977372779 @default.
- W2000808207 hasRelatedWork W1980923235 @default.
- W2000808207 hasRelatedWork W1988575162 @default.
- W2000808207 hasRelatedWork W2010440893 @default.
- W2000808207 hasRelatedWork W2012222268 @default.
- W2000808207 hasRelatedWork W2015642249 @default.
- W2000808207 hasRelatedWork W2051871841 @default.
- W2000808207 hasRelatedWork W2092244297 @default.
- W2000808207 hasRelatedWork W2170699625 @default.
- W2000808207 hasRelatedWork W2475014436 @default.
- W2000808207 hasVolume "22" @default.