FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000808372> ?p ?o ?g. }

• W2000808372 endingPage "48" @default.
• W2000808372 startingPage "43" @default.
• W2000808372 abstract "A study was conducted to elucidate hormonal control of leptin receptor gene expression in primary cultures of porcine hepatocytes. Hepatocytes were isolated from swine and seeded into T-25 flasks. Cultures were established in medium containing fetal bovine serum for one day and switched to serum-free medium (William's E medium and 1 ng/mL insulin) for the remainder of the 3d culture period. For the final 24 h, medium was supplemented with porcine growth hormone (GH, 100 or 500 ng/mL), insulin-like growth factor 1 (IGF-1, 50 to 250 ng/mL) or triiodothyronine (T3, 100 ng/mL). RNA was extracted and relative quantitative RT-PCR was performed with primers for long form leptin receptor. Receptor expression was calculated relative to 18S rRNA. Insulin had no effect (P>0.05), while T3 increased leptin receptor mRNA abundance (P<0.05). Treatment with GH or IGF-I reduced leptin receptor expression (P<0.05). Phosphorylation of ERK1/2 in response to acute leptin treatment was inhibited by previous exposure to GH or IGF-I. Hepatocytes secreted IGF-I under basal conditions and this was enhanced by GH addition. These data suggest porcine hepatocytes may be less sensitive to leptin stimulation due to the actions of endogenous IGF-I on leptin receptor expression." @default.
• W2000808372 created "2016-06-24" @default.
• W2000808372 creator A5010213554 @default.
• W2000808372 creator A5064854723 @default.
• W2000808372 creator A5080533797 @default.
• W2000808372 creator A5085201082 @default.
• W2000808372 date "2010-01-01" @default.
• W2000808372 modified "2023-09-27" @default.
• W2000808372 title "IGF-I mediated inhibition of leptin receptor expression in porcine hepatocytes" @default.
• W2000808372 cites W1580569338 @default.
• W2000808372 cites W1619222041 @default.
• W2000808372 cites W1836046792 @default.
• W2000808372 cites W1977073138 @default.
• W2000808372 cites W1996517295 @default.
• W2000808372 cites W1999074010 @default.
• W2000808372 cites W2001716823 @default.
• W2000808372 cites W2001812580 @default.
• W2000808372 cites W2021545003 @default.
• W2000808372 cites W2022420133 @default.
• W2000808372 cites W2035649153 @default.
• W2000808372 cites W2040190223 @default.
• W2000808372 cites W2042899826 @default.
• W2000808372 cites W2053299182 @default.
• W2000808372 cites W2059330847 @default.
• W2000808372 cites W2067534946 @default.
• W2000808372 cites W2068490358 @default.
• W2000808372 cites W2072167273 @default.
• W2000808372 cites W2075254346 @default.
• W2000808372 cites W2085529816 @default.
• W2000808372 cites W2090403820 @default.
• W2000808372 cites W2109311297 @default.
• W2000808372 cites W2140506341 @default.
• W2000808372 cites W2169828269 @default.
• W2000808372 cites W2217844268 @default.
• W2000808372 cites W2225160144 @default.
• W2000808372 cites W2332731601 @default.
• W2000808372 cites W2413483303 @default.
• W2000808372 cites W2417901579 @default.
• W2000808372 cites W51541032 @default.
• W2000808372 cites W70786305 @default.
• W2000808372 doi "https://doi.org/10.1016/j.cbpb.2009.09.007" @default.
• W2000808372 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19786114" @default.
• W2000808372 hasPublicationYear "2010" @default.
• W2000808372 type Work @default.
• W2000808372 sameAs 2000808372 @default.
• W2000808372 citedByCount "5" @default.
• W2000808372 countsByYear W20008083722013 @default.
• W2000808372 countsByYear W20008083722014 @default.
• W2000808372 countsByYear W20008083722015 @default.
• W2000808372 crossrefType "journal-article" @default.
• W2000808372 hasAuthorship W2000808372A5010213554 @default.
• W2000808372 hasAuthorship W2000808372A5064854723 @default.
• W2000808372 hasAuthorship W2000808372A5080533797 @default.
• W2000808372 hasAuthorship W2000808372A5085201082 @default.
• W2000808372 hasConcept C104317684 @default.
• W2000808372 hasConcept C113675107 @default.
• W2000808372 hasConcept C126322002 @default.
• W2000808372 hasConcept C134018914 @default.
• W2000808372 hasConcept C14372207 @default.
• W2000808372 hasConcept C150194340 @default.
• W2000808372 hasConcept C170493617 @default.
• W2000808372 hasConcept C2775960820 @default.
• W2000808372 hasConcept C2778288131 @default.
• W2000808372 hasConcept C2779306644 @default.
• W2000808372 hasConcept C2779404806 @default.
• W2000808372 hasConcept C2780613262 @default.
• W2000808372 hasConcept C2780689927 @default.
• W2000808372 hasConcept C2984496839 @default.
• W2000808372 hasConcept C511355011 @default.
• W2000808372 hasConcept C54355233 @default.
• W2000808372 hasConcept C55493867 @default.
• W2000808372 hasConcept C71315377 @default.
• W2000808372 hasConcept C71924100 @default.
• W2000808372 hasConcept C81885089 @default.
• W2000808372 hasConcept C86803240 @default.
• W2000808372 hasConceptScore W2000808372C104317684 @default.
• W2000808372 hasConceptScore W2000808372C113675107 @default.
• W2000808372 hasConceptScore W2000808372C126322002 @default.
• W2000808372 hasConceptScore W2000808372C134018914 @default.
• W2000808372 hasConceptScore W2000808372C14372207 @default.
• W2000808372 hasConceptScore W2000808372C150194340 @default.
• W2000808372 hasConceptScore W2000808372C170493617 @default.
• W2000808372 hasConceptScore W2000808372C2775960820 @default.
• W2000808372 hasConceptScore W2000808372C2778288131 @default.
• W2000808372 hasConceptScore W2000808372C2779306644 @default.
• W2000808372 hasConceptScore W2000808372C2779404806 @default.
• W2000808372 hasConceptScore W2000808372C2780613262 @default.
• W2000808372 hasConceptScore W2000808372C2780689927 @default.
• W2000808372 hasConceptScore W2000808372C2984496839 @default.
• W2000808372 hasConceptScore W2000808372C511355011 @default.
• W2000808372 hasConceptScore W2000808372C54355233 @default.
• W2000808372 hasConceptScore W2000808372C55493867 @default.
• W2000808372 hasConceptScore W2000808372C71315377 @default.
• W2000808372 hasConceptScore W2000808372C71924100 @default.
• W2000808372 hasConceptScore W2000808372C81885089 @default.
• W2000808372 hasConceptScore W2000808372C86803240 @default.
• W2000808372 hasIssue "1" @default.
• W2000808372 hasLocation W20008083721 @default.

• next