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- W2000808878 abstract "This study uses an operant, behavioral model to assess the daily changes in the decay rate of short-term memory, motivation, and motor ability in rats exposed to chronic restraint. Restraint decreased reward-related motivation by 50% without altering memory decay rate or motor ability. Moreover, chronic restraint impaired hippocampal-dependent spatial memory on the Y maze (4-hr delay) and produced CA3 dendritic retraction without altering hippocampal-independent maze navigation (1-min delay) or locomotion. Thus, mechanisms underlying motivation for food reward differ from those underlying Y maze exploration, and neurobiological substrates of spatial memory, such as the hippocampus, differ from those that underlie short-term memory. Chronic restraint produces functional, neuromorphological, and physiological alterations that parallel symptoms of depression in humans." @default.
- W2000808878 created "2016-06-24" @default.
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- W2000808878 date "2006-01-01" @default.
- W2000808878 modified "2023-10-16" @default.
- W2000808878 title "Chronic stress impairs spatial memory and motivation for reward without disrupting motor ability and motivation to explore." @default.
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- W2000808878 doi "https://doi.org/10.1037/0735-7044.120.4.842" @default.
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