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- W2000809172 abstract "Experiments were conducted to determine why 10,10-difluoro,13-dehydroprostacyclin (DF2-PGI2) has a long vascular relaxant activity in vitro but like PGI2 has a short duration of effect in vivo. DF2-PGI2 produced depressor responses in anesthetized dogs which were not affected by nephrectomy suggesting that the kidney was not responsible for the termination of action. DF2-PGI2 given intravenously or into the ascending aorta produced depressor responses of a similar magnitude but injection of the same doses into the hepatic portal circulation resulted in a large attenuation of responses. The data suggest hepatic, but not pulmonary, metabolism of DF2-PGI2. Injection or infusion of PGI2 and DF2-PGI2 into the hindlimb circulation caused vasodilatation of a similar duration suggesting diffusion from tissue sites as another mechanism of termination of action." @default.
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- W2000809172 date "1983-03-01" @default.
- W2000809172 modified "2023-09-23" @default.
- W2000809172 title "Factors affecting the termination of cardiovascular actions of 10, 10-difluoro, 13-dehydroprostacyclin" @default.
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- W2000809172 doi "https://doi.org/10.1016/0090-6980(83)90048-5" @default.
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