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• W2000809967 abstract "안와 림프종의 치료에 가장 효과적인 치료법인 방사선 치료는 안구 질환의 증가로 인해 계속 늘어나는 추세이다. 항암화학요법과 치료 기술의 비약적인 발전으로 치료 및 예후가 좋아지고는 있지만 백내장, 안구건조, 망막병증 등의 부작용이 발생되고 있다. 이에 본 연구에서는 안와 림프종의 방사선치료 시 백내장 발생의 방어수단으로써 Lens Shielding Device(이하 LSD)를 고안 제작하였고 이의 제작방법과 방사선 차폐 정도에 대해 알아보았다. 안구 표면에 해당하는 깊이에서 TLD의 측정결과는 3개의 평균값이 5.7%로 나타났고 관심부위인 수정체의 위치에서는 TLD 4.2%, markus chamber 5.1%의 선량값을 나타내었다. 본 연구에서 안와에 발생한 림프종의 방사선 치료로 인한 부작용을 예방하기 위해 제작한 LSD는 치료 중 조사받게 되는 총 30Gy의 선량 중에서 5%에 해당하는 약 1.5Gy의 방사선량만이 수정체와 각막에 영향을 미치는 것으로 확인되어 백내장의 역치선량인 2Gy와 임상적으로 백내장이 발생된다고 보고된 5Gy보다 적은 선량이 조사됨을 알 수 있었다. 방사선 치료 시 발생할 수 있는 여러 부작용의 예방에 유용한 기구임을 확인하였고 환자의 안구와 일치되도록 개인별로 제작하여 착용 시 이물감에 의한 불편을 줄일 수 있을 뿐만 아니라 치료 시 고정 또한 매우 용이함을 검증하였다. Radiotherapy which is the most effective for orbit lymphoma has been used increasingly due to the increase of orbit or ocular adnexal tumor patients. Curative effects and convalescence have been being more satisfied thanks to remarkable development of cancer chemotherapy and medical treatments, but side effects such as cataract, dry eye and retinopathy still break out. Thus, in this study, a Lens Shielding Device (LSD hereafter) was designed to prevent occurring of cataract due to radiation therapy for orbit lymphoma and its efficacy through dosimetry were evaluated. And in this paper, its manufacturing process was also explained. LSD is composed of a cover body covering the lens and a side fixing part supporting the cover body. To measure radiation, the patient therapy conditions were simulated and the measurement of the radiation was conducted with Thermo Luminescence Detector (TLD) and Markus chamber. The average TLD value was 5.7% and the TLD value and Markus chamber value were acquired as 4.2% and 5.1% respectively at 6 mm depth where zero lens center was located. Only 1.5Gy (<TEX>$300Gy{times};5%$</TEX>) or 5% of total 30Gy with 9 MeV electron beam is estimated to affect on patient's lens. That is smaller dose than the threshold value of cataract (2GY) or the value (5Gy) that was reported to cause cataract in clinical conditions. Thus, these findings suggest that LSD be very useful for prevention of cataract during radiotherapy for malignant lymphoma of orbit and ocular adnexa. Furthermore, it might be possible to reduce patient's discomfort caused by alien substances and to make it easier to fix the device with customized manufacturing manners." @default.
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• W2000809967 date "2007-12-28" @default.
• W2000809967 modified "2023-10-18" @default.
• W2000809967 title "Efficacy of Lens Shielding Device to Prevent Cataract with Radiotherapy for Orbit or Ocular Adnexal Tumor" @default.
• W2000809967 doi "https://doi.org/10.5392/jkca.2007.7.12.139" @default.
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