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- W2000810293 abstract "We followed up five infants from birth to five years of age for the shedding of rotavirus and the appearance of IgA antibody in the feces, in order to know the relation of rotavirus infections with diarrheal symptoms and the host's responses in fecal IgA antibody production. We collected fecal samples basically once a week from the infants, and evaluated the contents of rotayirus antigen and antibody and total IgA in all the samples by enzyme-linked immunosorbent assays. We also detected virus particles in some concentrated samples by electron microscopy. We found that all the infants shed a large amount of rotavirus in the winter seasons up to two years of age, but two infants showed no symptoms of diarrhea. After primary infection, the specific IgA index, defined as the specific IgA antibody titer divided by the total IgA concentration of each feces, rose and fluctuated from time to time. However, we observed occasional eight fold or greater rises in the index between two consecutive fecal samples, suggesting anamnestic responses in fecal IgA antibody production. Some of the rises were accompanied with mild diarrhea and the presence of a low amount of virus in the feces detected by electron microscopy. Probably, repeated mild reinfections with rotavirus are occurring in infants at all seasons." @default.
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- W2000810293 date "1988-08-01" @default.
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- W2000810293 title "Long-Term Follow-Up of Infants from Birth for Rotavirus Antigen and Antibody in the Feces" @default.
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- W2000810293 doi "https://doi.org/10.1111/j.1442-200x.1988.tb02542.x" @default.
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